Results 191 to 200 of about 5,457,303 (315)

The prognostic significance of the IASLC grading system in ALK-positive invasive non-mucinous adenocarcinoma of the lung: correlation with clinicopathological features. [PDF]

J Pathol Clin Res
Gu D, Bao J, Chen H, Chen S, Shi C, Guo X, Zhou X, Lei Z, Guo L, Yang Q.   +9 more
europepmc   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

STYK1 expression in breast cancer and its association with vascular invasion and clinicopathological features. [PDF]

Sci Rep
Mohammed R, Ismaeel A, Alshaikh S, Mubarak A, Sabt S, Selvam S.   +5 more
europepmc   +1 more source

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

Interdisciplinary Medicine, EarlyView.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang, Fan Zou, Mingdong Wang, Chenyue Wu, Yingwei Xie, Yongjun Quan, Wei Yan, Yupeng Zheng, Lianhua Li, Yuexin Liu, Jian Yu, Hao Ping   +11 more
wiley   +1 more source

Clinicopathological Features of Superficial Non-Ampullary Duodenal Epithelial Tumors Involving Brunner's Glands. [PDF]

DEN Open
Takayama K, Iwatsubo T, Ishida M, Sasaki S, Hakoda A, Sugawara N, Ota K, Takeuchi T, Kawaguchi N, Tomioka A, Tanaka R, Asakuma M, Lee SW, Higuchi K, Hirose Y, Nishikawa H.   +15 more
europepmc   +1 more source

Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
MMP1 and TGFBR2 were validated by machine learning and external datasets as the candidate genes. Dexamethasone showed strong binding affinity to MMP1 (−7.72 kcal/mol) and TGFBR2 (−7.27 kcal/mol) in docking studies. Knockdown of MMP1 repressed the malignant phenotypes of NPC cells.
Feng Wang, Binbin Ge, Ming Li, Xiaochun Xia, Fuming Zhang, Pengqin Xu   +5 more
wiley   +1 more source

Prediction of pathologic upstaging in ductal carcinoma in situ using MRI radiomics combined with clinicopathological features. [PDF]

Breast Cancer Res
Bi C, Li Q, Deng L, Ren Z, Sun D, Ran F, Hu Z, Wang R, Sun S, Yang S, Chen A, Zhao R, Gao D, Wang J, Yang J.   +14 more
europepmc   +1 more source

High‐Frequency Ultrasonographic Characterization of Subcutaneous Glomus Tumors

Journal of Clinical Ultrasound, EarlyView.
Color Doppler image reveals intralesional hypervascularity. ABSTRACT Objective To evaluate the clinical manifestations and ultrasonographic characteristics of glomus tumors under the nails and other subcutaneous soft tissues. Methods A retrospective analysis was performed on 45 patients with pathologically confirmed glomus tumors who underwent ...
Mingyu Bai, Nan Wang, Jie Jiang
wiley   +1 more source

Clinicopathological features and prognosis of primary pulmonary lymphoepithelioma-like carcinoma.

Journal of Thoracic Disease, 2016
Wen-yang Jiang, Rui Wang, Xu-feng Pan, Yu-zhou Shen, Tianxiang Chen, Yunhai Yang, J. Shao, Lei Zhu, B. Han, Jun Yang, Heng Zhao   +10 more
semanticscholar   +1 more source