Results 91 to 100 of about 264,799 (308)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Comparison of BrdU-CLIP and optimized CLIP.
, 2020 Before PCR amplification, radiolabeled CLIP cDNA libraries were separated by 10% TBE-urea PAGE (A), and signal intensities were quantified (B). Signal intensities were measured between 66 and 200 nt; Averaged HNRNPU CLIP library signal intensities for ...
Hideyuki Okano (47690) +3 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Frontiers in Neurology, 2017 The persistent primitive hypoglossal artery (PPHA) is the second most common persistent carotid–vertebrobasilar anastomosis, with an incidence of 0.027–0.26%.
Shu Wan +6 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Open Information ScienceRecent advances in multimodal learning have significantly enhanced natural language understanding (NLU) and information retrieval across various languages; however, Arabic remains substantially underrepresented in this domain. In this work, we propose an
Harrag Fouzi +3 more
doaj +1 more source
Applied SciencesThe number of pistons in axial piston pumps plays a significant role in determining the performance characteristics of the pump. While increasing the number of pistons can improve capacity, stability, and flow, it also requires careful consideration of ...
Milan Radosavljević +5 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source