Results 121 to 130 of about 264,799 (308)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

RL-CWtrans Net: multimodal swimming coaching driven via robot vision

open access: yesFrontiers in Neurorobotics
In swimming, the posture and technique of athletes are crucial for improving performance. However, traditional swimming coaches often struggle to capture and analyze athletes' movements in real-time, which limits the effectiveness of coaching. Therefore,
Guanlin Wang
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Clip‐Centered Common Bile Duct Stones Managed by Endoscopic Sphincterotomy Plus Endoscopic Papillary Large Balloon Dilation Years After Cholecystectomy

open access: yesDEN Open
Migration of clips used in laparoscopic cholecystectomy (LC) is rare, but when a clip migrates into the bile duct, it can serve as a nucleus for common bile duct stone formation and trigger acute cholangitis.
Nobuhiko Fukuba   +7 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Early Fusion of Visual and Ingredient Representations for Multimodal Food Classification

open access: yesJOIN: Jurnal Online Informatika
Identifying the most appropriate food dish based on available kitchen ingredients remains a practical yet challenging task in everyday life. To address this, this study specifically aims to develop an intelligent food classification system using a ...
Navira Rahma Salsabila   +3 more
doaj   +1 more source

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