Why gradient clipping accelerates training: A theoretical justification for adaptivity [PDF]
Jingzhao Zhang +3 more
openalex +1 more source
Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD
Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du +6 more
wiley +1 more source
Endovascular treatment outcomes in patients with residual cerebral aneurysmatic filling after open surgery. [PDF]
Gurpinar I +4 more
europepmc +1 more source
Bio‐Based Wax Interfaces for Droplet Energy Harvesting at Fluoropolymer‐Like Output Levels
Replacing unsustainable fluorinated polymers in droplet‐based energy harvesters is usually limited by low power outputs, but carefully selected bio‐based polymers are capable of creating fluoropolymer‐like voltage outputs. Abstract Droplet impact and rebound on solid surfaces has emerged as a promising method for energy harvesting, typically ...
Behnam Kamare +4 more
wiley +1 more source
A simulation study of the cost of cerebral vasospasm treatments with clazosentan: A mathematical model using time-driven activity-based costing. [PDF]
Zhao J +5 more
europepmc +1 more source
Management protocol for emergency aneurysm craniotomy clipping in non-major COVID-19 epidemic areas in Beijing, China [PDF]
Yú Chen +14 more
openalex +1 more source
OBUSight: Clinically Aligned Generative AI for Ophthalmic Ultrasound Interpretation and Diagnosis
OBUSight, a clinically aligned generative AI model that jointly generates reports and predicts diseases through multimodal semantic alignment, was trained and validated on a large multicenter dataset. OBUSight outperformed eight state‐of‐the‐art models, provided clinically reliable reports, enhanced diagnostic efficiency, and achieved performance ...
Xiaocong Liu +17 more
wiley +1 more source
Clinical Practice Guideline for the Prehospital Stage of Acute Stroke : III. Initial Decision for Primary Treatment in Subarachnoid Hemorrhage. [PDF]
Oh JS +25 more
europepmc +1 more source
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen +10 more
wiley +1 more source

