Results 31 to 40 of about 4,199 (162)
eLife, 2021 Entry into the cell cycle occurs only when sufficient growth has occurred. In budding yeast, the cyclin Cln3 is thought to initiate cell cycle entry by inactivating a transcriptional repressor called Whi5.
Robert A Sommer +3 more
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Dual Repressive Function by Cip1, a Budding Yeast Analog of p21, in Cell-Cycle START Regulation
Frontiers in Microbiology, 2020 Cip1, a newly identified yeast analog of p21, is a Cln3-CDK inhibitor that negatively regulates cell-cycle START. However, its function remains poorly understood.
Pan Li +11 more
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Drug-induced hyperthermia with rhabdomyolysis in CLN3 disease
European Journal of Paediatric Neurology, 2022 CLN3 disease (MIM# 204200), the most prevalent of the neuronal ceroid lipofuscinoses (NCL), is an autosomal recessive disorder with juvenile onset characterized by blindness, epilepsy, dementia, psychiatric manifestations, and motor deterioration. Problems related to behavior, emotions and thought are among the main features.
A, Savvidou +5 more
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Neurobiology of Disease, 2006 Batten disease, a lysosomal storage disorder, is caused by mutations in the CLN3 gene. The Cln3-knockout (Cln3−/−) mouse model of the disease exhibits many characteristic pathological features of the human disorder.
Attila D. Kovács +2 more
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, 2023 smFISH Data of the A. gossypii cyclin CLN3, supporting the work "The Role of RNA Phase Separation in Noise Suppression". Each of the 15 hyphae imaged have four associated data sets: the raw (deconvolved) image data, detected RNA locations, hyphal masks, and nuclear masks.
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The yeast Cln3 protein is an unstable activator of Cdc28. [PDF]
Molecular and Cellular Biology, 1993 The Cln3 cyclin homolog of Saccharomyces cerevisiae functions to promote cell cycle START for only a short time following its synthesis. Cln3 protein is highly unstable and is stabilized by C-terminal truncation. Cln3 binds to Cdc28, a protein kinase catalytic subunit essential for cell cycle START, and Cln3 instability requires Cdc28 activity.
F R, Cross, C M, Blake
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Neurodegeneration and Epilepsy in a Zebrafish Model of CLN3 Disease (Batten Disease). [PDF]
PLoS ONE, 2016 The neuronal ceroid lipofuscinoses are a group of lysosomal storage disorders that comprise the most common, genetically heterogeneous, fatal neurodegenerative disorders of children.
Kim Wager +5 more
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Biology Open, 2014 Wolfram syndrome (WFS) is a progressive neurodegenerative disease characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. WFS1 and WFS2 are caused by recessive mutations in the genes Wolfram Syndrome 1 (WFS1) and CDGSH iron ...
Melanie A. Jones +12 more
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Disease Models & Mechanisms, 2015 Mutations in the CLN3 gene cause a fatal neurodegenerative disorder: juvenile CLN3 disease, also known as juvenile Batten disease. The two most commonly utilized mouse models of juvenile CLN3 disease are Cln3-knockout (Cln3−/−) and Cln3Δex7/8-knock-in ...
Attila D. Kovács, David A. Pearce
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Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes
Epilepsia Open, EarlyView.Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola +3 more
wiley +1 more source