Results 131 to 140 of about 1,324,164 (376)

Extracting dark matter signatures from atomic clock stability measurements

, 2017
We analyze possible effects of the dark matter environment on the atomic clock stability measurements. The dark matter is assumed to exist in a form of waves of ultralight scalar fields or in a form of topological defects (monopoles and strings).
Kalaydzhyan, Tigran, Yu, Nan
core   +1 more source

mTOR signaling regulates central and peripheral circadian clock function

PLoS Genetics, 2018
The circadian clock coordinates physiology and metabolism. mTOR (mammalian/mechanistic target of rapamycin) is a major intracellular sensor that integrates nutrient and energy status to regulate protein synthesis, metabolism, and cell growth.
C. Ramanathan, Nimish D Kathale, Dong Liu, Choogon Lee, D. Freeman, J. Hogenesch, R. Cao, A. C. Liu   +7 more
semanticscholar   +1 more source

Cnidarians are CLOCKing in

eLife
Studies of the starlet sea anemone provide important insights into the early evolution of the circadian clock in animals.
Erica R Kwiatkowski, Patrick Emery
openaire   +3 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Disruption of the Clock Components CLOCK and BMAL1 Leads to Hypoinsulinemia and Diabetes

Nature, 2010
The molecular clock maintains energy constancy by producing circadian oscillations of rate-limiting enzymes involved in tissue metabolism across the day and night.
B. Marcheva, Kathryn Moynihan Ramsey, Ethan D. Buhr, Yumiko Kobayashi, Hong Su, C. H. Ko, Ganka Ivanova, Chiaki Omura, Shelley Mo, M. Vitaterna, James P. Lopez, L. Philipson, C. Bradfield, S. Crosby, L. JeBailey, Xiaozhong Wang, J. Takahashi, J. Bass   +17 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Marmaracık- Köylüce- Kızılca Köyleri Mosques and Its Painting Works (Demirci –Manisa)

Art-Sanat
The establishment date of Demirci, one of the districts farthest from Manisa city center, is not exactly known. It is possible to see the traces of different civilizations from every age of history in the town center and its villages. The ancient city of
Serap Erçin Koçer
doaj   +1 more source

Making optical atomic clocks more stable with $10^{-16}$ level laser stabilization

, 2011
The superb precision of an atomic clock is derived from its stability. Atomic clocks based on optical (rather than microwave) frequencies are attractive because of their potential for high stability, which scales with operational frequency. Nevertheless,
A. D. Ludlow, AD Ludlow, AD Ludlow, B Young, C. W. Oates, CW Chou, CW Chou, G Santarelli, H Katori, J Millo, J Ye, J. A. Sherman, K Numata, L.-S. Ma, LS Ma, M Notcutt, MD Swallows, MM Boyd, N Nakagawa, N. D. Lemke, ND Lemke, PG Westergaard, R. W. Fox, RW Fox, S Bize, S Webster, SA Webster, ST Dawkins, T Legero, T Udem, WM Itano, Y Levin, Y. Y. Jiang   +32 more
core   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source