Quantitative analysis of regulatory flexibility under changing environmental conditions [PDF]
, 2010 The circadian clock controls 24-h rhythms in many biological processes, allowing appropriate timing of biological rhythms relative to dawn and dusk. Known clock circuits include multiple, interlocked feedback loops.
Adrian W Thomson +12 more
core +4 more sources
Clinical Profiles of Dengue Infection during an Outbreak in Northern India
Journal of Tropical Medicine, 2016 Introduction. Dengue fever is an arboviral disease, which is transmitted by mosquito vector and presents as varied clinical spectrum of dengue fever (DF), dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS), and expanded dengue syndrome (EDS ...
Anish Laul +5 more
doaj +1 more source
A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line [PDF]
, 2019 The circadian clock regulates key cellular processes and its dysregulation is associated to several pathologies including cancer. Although the transcriptional regulation of gene expression by the clock machinery is well described, the role of the clock ...
Abreu, Mónica +4 more
core +1 more source
Cinnamic acid shortens the period of the circadian clock in mice
Biochemistry and Biophysics Reports, 2017 Cinnamic acid (CA) derivatives have recently received focus due to their anticancer, antioxidant, and antidiabetic properties. The present study aimed to determine the effects of cinnamic acid on the circadian clock, which is a cell-autonomous endogenous
Katsutaka Oishi +4 more
doaj +1 more source
Сибирский онкологический журнал, 2021 Purpose of the study: to review in vivo studies on the relationship and role of various molecular genetic components of the circadian rhythm system in the initiation and development of malignant neoplasms.
G. S. Kireeva +8 more
doaj +1 more source
Probabilistic Timed Automata with Clock-Dependent Probabilities [PDF]
, 2017 Probabilistic timed automata are classical timed automata extended with discrete probability distributions over edges. We introduce clock-dependent probabilistic timed automata, a variant of probabilistic timed automata in which transition probabilities ...
A Abate +13 more
core +2 more sources
Coronary Anomalies: Left Main Coronary Artery Aneurysm
Case Reports in Cardiology, 2012 Coronary artery aneurysm is one of the rarest anomalies that we see in our medical practice and they are mostly associated with obstructive lesions due to atherosclerotic changes.
Rajsekhar Varda +2 more
doaj +1 more source
Effects of Kamikihito and Unkei-to on Sleep Behavior of Wild Type and Parkinson Model in Drosophila
Frontiers in Psychiatry, 2017 Parkinson’s disease (PD) is the second most common neurodegenerative disease, and it is associated with sleep behavior disorders. In Drosophila melanogaster disease model, human α-synuclein A30P overexpressing flies (A30P PD model) have been shown for ...
Kumpei Ito +11 more
doaj +1 more source
Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex
bioRxiv, 2020 Human DNA-methylation data have been used to develop biomarkers of ageing - referred to ‘epigenetic clocks’ - that have been widely used to identify differences between chronological age and biological age in health and disease including ...
Gemma L Shireby +16 more
semanticscholar +1 more source
Evaluating Circadian Dysfunction in Mouse Models of Alzheimer’s Disease: Where Do We Stand?
Frontiers in Neuroscience, 2020 Circadian dysfunction has been described in patients with symptomatic Alzheimer’s disease (AD), as well as in presymptomatic phases of the disease. Modeling this circadian dysfunction in mouse models would provide an optimal platform for understanding ...
Patrick W. Sheehan +2 more
doaj +1 more source