Results 51 to 60 of about 1,324,164 (376)
Cell-autonomous clock of astrocytes drives circadian behavior in mammals
Science, 2019 Astrocytes can drive the master clock in the brain The neurons of the suprachiasmatic nucleus (SCN) of the hypothalamus function as a central circadian clock, coordinating mammalian physiology with the 24-hour light-dark cycle. Brancaccio et al.
M. Brancaccio +6 more
semanticscholar +1 more source
Scientific Reports, 2017 We recently found that the mRNA expression of Slc25a25, a Ca2+-sensitive ATP carrier in the inner mitochondrial membrane, fluctuates in a circadian manner in mouse skeletal muscle.
Reiko Nakao +2 more
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Frequency ratios of Sr, Yb and Hg based optical lattice clocks and their applications [PDF]
, 2015 This article describes the recent progress of optical lattice clocks with neutral strontium ($^{87}$Sr), ytterbium ($^{171}$Yb) and mercury ($^{199}$Hg) atoms.
Akatsuka, Tomoya +10 more
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The molecular clock may be an episodic clock. [PDF]
Proceedings of the National Academy of Sciences, 1984 It is argued that the apparent constancy of the rate of molecular evolution may be an artifact due to the very slow rate of evolution of individual amino acids. A statistical analysis of protein evolution using a stationary point process as the null hypothesis leads to the conclusion that molecular evolution is episodic, with short bursts of rapid ...
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The Journals of Gerontology: Series A, 2021 Abstract The immune system has been for long considered a marker of health. The age-related decline in its function results in a greater incidence of infections, autoimmune diseases, and cancer. Nevertheless, it is still not known if immune function can be used to accurately estimate the rate of aging of an individual. A set of 14 immune
Carmen Vida +3 more
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Rodent models for the analysis of tissue clock function in metabolic rhythms research [PDF]
, 2017 The circadian timing system consists on a distributed network of cellular clocks that together coordinate 24-h rhythms of physiology and behavior. Clock function and metabolism are tightly coupled, from the cellular to the organismal level.
Astiz, Mariana +3 more
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A balance of positive and negative regulators determines the pace of the segmentation clock
eLife, 2015 Somitogenesis is regulated by a molecular oscillator that drives dynamic gene expression within the pre-somitic mesoderm. Previous mathematical models of the somitogenesis clock that invoke the mechanism of delayed negative feedback predict that its ...
Guy Wiedermann +5 more
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The Clock Takes Shape—24 h Dynamics in Genome Topology
Frontiers in Cell and Developmental Biology, 2022 Circadian rhythms orchestrate organismal physiology and behavior in order to anticipate daily changes in the environment. Virtually all cells have an internal rhythm that is synchronized every day by Zeitgebers (environmental cues). The synchrony between
Kévin Tartour, Kiran Padmanabhan
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Two-phase RTD-CMOS pipelined circuits [PDF]
, 2012 MOnostable-BIstable Logic Element (MOBILE) networks can be operated in a gate-level pipelined fashion (nanopipeline) allowing high through output. Resonant tunneling diode (RTD)-based MOBILE nanopipelined circuits have been reported using different clock
Avedillo de Juan, María José +2 more
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Molecular mechanism of the repressive phase of the mammalian circadian clock
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The circadian clock mechanism is a daily rhythmic activation of circadian gene transcription by the CLOCK–BMAL1 heterodimer and repression by CRYs (CRY1 and CRY2) and PERs (PER1 and PER2).
Xuemei Cao +4 more
semanticscholar +1 more source