Results 51 to 60 of about 1,354,268 (327)
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Non-obesogenic doses of palmitate disrupt circadian metabolism in adipocytes
Adipocyte, 2019 Saturated fatty acids, such as palmitate, lead to circadian disruption. We aimed at studying the effect of low doses of palmitate on circadian metabolism and to decipher the mechanism by which fatty acids convey their effect in adipocytes.
Yael Tal, Nava Chapnik, Oren Froy
doaj +1 more source
Біологічні студії, 2011 The main molecular components of circadian clock system are proteins which play a significant role in the control of both metabolism and malignant tumor growth.
L. L. Karbovskyi +4 more
doaj +1 more source
Two-phase RTD-CMOS pipelined circuits [PDF]
, 2012 MOnostable-BIstable Logic Element (MOBILE) networks can be operated in a gate-level pipelined fashion (nanopipeline) allowing high through output. Resonant tunneling diode (RTD)-based MOBILE nanopipelined circuits have been reported using different clock
Avedillo de Juan, María José +2 more
core +2 more sources
Molecular mechanism of the repressive phase of the mammalian circadian clock
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The circadian clock mechanism is a daily rhythmic activation of circadian gene transcription by the CLOCK–BMAL1 heterodimer and repression by CRYs (CRY1 and CRY2) and PERs (PER1 and PER2).
Xuemei Cao +4 more
semanticscholar +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Processing circuit with asymmetry corrector and convolutional encoder for digital data [PDF]
, 1987 A processing circuit is provided for correcting for input parameter variations, such as data and clock signal symmetry, phase offset and jitter, noise and signal amplitude, in incoming data signals.
Pfiffner, Harold J.
core +1 more source
A Fermi-degenerate three-dimensional optical lattice clock [PDF]
Science, 2017 Making a denser optical lattice clock Some of today's most advanced clocks are made up of large numbers of atoms lined up in a one-dimensional (1D) optical lattice. The numbers improve clock stability, but atomic interactions can limit accuracy. Campbell
S. L. Campbell +10 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Estimating Polar Bear (Ursus maritimus) Age Based on an Epigenetic DNA Methylation Clock
Ecology and EvolutionKnowledge of animal age is essential to wildlife managers for obtaining meaningful and accurate insights into demographic parameters. A common approach to aging wildlife, including bears (Ursus spp.), has been extracting a tooth during physical capture ...
Susannah P. Woodruff +4 more
doaj +1 more source