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Aging is closely linked to various health challenges, including cardiovascular disease, metabolic disorders, and neurodegenerative conditions.
Youngji Han+2 more
doaj +1 more source
Evolution of clock escapement mechanisms [PDF]
The paper presents and explains the evolution of details design of the clock escapement mechanisms through the ages. As particularly significant, the following mechanisms are emphasized: the crown wheel (verge & foliot), anchor recoil, deadbeat and ...
Stoimenov Miodrag+3 more
doaj
The main molecular components of circadian clock system are proteins which play a significant role in the control of both metabolism and malignant tumor growth.
L. L. Karbovskyi+4 more
doaj +1 more source
Dependence of the time-reading process of the Salecker--Wigner quantum clock on the size of the clock [PDF]
It is shown in the present note that the degree of the complexity of the time-reading process of the Salecker--Wigner clock depends on the size of the clock. This dependence leads to a relation between the size and the accuracy of the clock, and suggests
Frenkel, Andor
core +2 more sources
Infection Models for Pine Wilt Disease on the Basis of Vector Behaviors
Infection models for pine wilt disease without vector density were built to estimate the transmission coefficient of the pathogenic nematode. The models successfully simulated the annual change in the density of infected trees for four pine stands. ABSTRACT Pine wilt disease is caused by the pinewood nematode (Bursaphelenchus xylophilus Steiner et ...
Katsumi Togashi
wiley +1 more source
Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock.
Glioblastomas are highly lethal cancers, containing self-renewing glioblastoma stem cells (GSCs). Here, we show that GSCs, differentiated glioblastoma cells (DGCs), and non-malignant brain cultures all displayed robust circadian rhythms, yet GSCs alone ...
Zhen Dong+19 more
semanticscholar +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Circadian Control of Inflammasome Pathways: Implications for Circadian Medicine
The innate immune system senses “non-self” molecules derived from pathogens (PAMPs) as well as endogenous damage-associated molecular patterns (DAMPs) and promotes sterile inflammation that is necessary for injury resolution, tissue repair/regeneration ...
Benoit Pourcet, Hélène Duez
doaj +1 more source
Residual discrete symmetry of the five-state clock model
It is well-known that the $q$-state clock model can exhibit a Kosterlitz-Thouless (KT) transition if $q$ is equal to or greater than a certain threshold, which has been believed to be five. However, recent numerical studies indicate that helicity modulus
Baek, Seung Ki+3 more
core +1 more source