Results 41 to 50 of about 421,093 (221)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Other title: Connecticut substance abuse prevention and treatment block grant
, 2017 Biennial; At head of title: Connecticut.; "Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment, Center for Substance Abuse Prevention.
Connecticut. Department of Mental Health and Addiction Services.
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Other title: Kansas Substance Abuse Policy Board January 2009 Report
, 2009 Annual.; January 2009.; "Established by the Kansas Criminal Justice Coordinating Council."; "The Governor and the 2008 Legislature authorized the creation of the Substance Abuse Policy Board (SAPB) under the auspices of the Kansas Criminal Justice ...
Kansas Substance Abuse Policy Board.
core
Brief interventions: mental health-substance use [PDF]
, 2011 INTRODUCTION This chapter provides a definition of brief interventions and charts their development both empirically and in terms of their theory base. Evidence is set out regarding the effects of brief interventions on substance use, including alcohol ...
Kaner, Eileen +2 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Other title: Connecticut substance abuse prevention and treatment block grant
, 2018 Biennial; At head of title: Connecticut.; "Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment, Center for Substance Abuse Prevention.
Connecticut. Department of Mental Health and Addiction Services.
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Substance abuse treatment, what do we know? [PDF]
, 2005 Substance abuse, Alcohol misuse, Survey, Treatment evaluation, Effectiveness,
Machado, Matilde P., Matilde Machado
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