FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Cross-talk between dopamine and noradrenaline modulates glutamatergic transmission in the deep cerebellar nuclei. [PDF]
Sci RepSaitow F, Arakawa R, Suzuki H.
europepmc +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
The critical human pathogen Acinetobacter baumannii exhibits light-regulated circadian rhythms. [PDF]
Commun BiolPermingeat V +11 more
europepmc +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Genomic diversity of uropathogenic Escherichia coli in clinical isolates from six latin american countries, 2018-2023. [PDF]
Rev Peru Med Exp Salud PublicaCaballero F +17 more
europepmc +1 more source
El derecho fundamental a la vida del clon humano
, 2011 La clonación humana es la técnica biotecnológica que reduce al hombre a una condición de cosa o instrumento, como justificación de aquella se suele alegar fundamentalmente la satisfacción del deseo paternal a parejas estériles y el beneficio a la salud de personas que padecen de alguna enfermedad grave; a la primera se la suele llamar clonación ...
openaire +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Thoracic spinal anesthesia with intrathecal sedation for lower back surgery: a retrospective cohort study. [PDF]
Front Med (Lausanne)Boykov N +5 more
europepmc +1 more source
Essential oil composition and total phenolic content in Cupressus arizonica G. in response to microbial inoculation under water stress conditions. [PDF]
Sci Rep, 2023 Aalipour H, Nikbakht A, Sabzalian MR.
europepmc +1 more source