Results 71 to 80 of about 18,527 (305)

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Evaluation of genetic parameters and clonal selection of Eucalyptus in the Cerrado region

Crop Breeding and Applied Biotechnology, 2020
Eucalyptus plantations in Brazil are expanding toward the northern and mid-western regions of the country. The objective of the present study was to select clones adapted to the local conditions, with a focus on the Cerrado region.
Rodrigo de Sousa Oliveira, Carlos Vinícius Gonçalves Ribeiro, Deisiany Ferreira Neres, Antônio Carlos da Mota Porto, Dalton Ribeiro, Leandro de Siqueira, Edival Ângelo Valverde Zauza, Alexandre Siqueira Guedes Coelho, Cristiane Aparecida Fioravante Reis, Acelino Couto Alfenas, Evandro Novaes   +10 more
doaj  

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Influence of the slope of terrain on the spatial variability of the wood density within Eucalyptus trees [PDF]

, 2012
The aim of this study was to understand how contrasting environments influence the wood formation in Eucalyptus clones and the effect on wood density and spatial variability.
Brancheriau, Loïc, Chaix, Gilles, Hein, Paulo Ricardo Gherardi, Lima, Jose Tarcisio, Moreira da Silva, Jose Reinaldo, Trugilho, Paulo Fernando   +5 more
core  

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Status of the "YSG Biotech" program of building up teak genetic resources in Sabah [PDF]

, 2009
Depuis le début des années 1990, le Plant Biotechnology Laboratory, projet de collaboration en recherche et développement entre la Division Forestière du Yayasan Sabah Group et le Centre de coopération internationale en recherche agronomique pour le ...
Goh, Doreen Kim Soh, Monteuuis, Olivier
core  

Carbon and nutrient stocks of tea plantations differing in age, genotype and plant population density [PDF]

, 2008
Tea (Camellia sinensis L.) is a perennial evergreen shrub managed intensively for continuous growth of young shoots. Most tea plantations were established at the expense of native forest. Change in carbon (C) and nutrient (nitrogen, phosphorus, potassium
Kamau, D.M., Oenema, O., Spiertz, J.H.J.
core   +3 more sources

Simulation as a method for asymptotic system behavior identification (e.g. water frog hemiclonal population systems) [PDF]

, 2020
Studying any system requires development of ways to describe the variety of its conditions. Such development includes three steps. The first one is to identify groups of similar systems (associative typology).
Biriuk, Olga, Kravchenko, Marina, Leonov, Anton, Mair, Quentin, Meleshko, Olena, Newman, Julian, Shabanov, Dmytro, Usova, Olena, Vladymyrova, Marina, Zholtkevych, Grygoriy   +9 more
core   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source