Results 101 to 110 of about 24,059 (302)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Photosensitive and conventional shading nets in the clonal propagation of hybrids of Eucalyptus spp. and the Corymbia spp. [PDF]

A miniestaquia é uma técnica de propagação vegetativa amplamente empregada na produção clonal de mudas de Eucalyptus spp. e Corymbia spp., sendo o minijardim clonal e a casa de vegetação ambientes fundamentais para o sucesso desse processo. Este trabalho
Paula, Jefferson Carneiro de
core   +2 more sources

Validated multiplex PCR of microsatellites for breeding purposes, clonal fidelity and controlled crosses in teak

Crop Breeding and Applied Biotechnology
Teak (Tectona grandis L.f), a valuable hardwood species, is widely cultivated for its superior wood properties. Effective breeding and clonal propagation programs require robust genetic verification methods such as clonal fidelity and parentage ...
Dawa Méndez-Álvarez, Emanuel Araya-Valverde, Yorleny Badilla-Valverde, Olman Murillo-Gamboa   +3 more
doaj  

Clonal propagation of Zephyranthes grandiflora using bulbs as explants

Biologia Plantarum, 2010
Zephyr lily (Zephyranthes grandiflora), an important ornamental plant has been micropropagated in vitro after controlling microbial contamination by a pretreatment with 0.2 % Bavistin and 0.1 % Pantomycin for 4 h before final sterilization with 0.1 ...
M. Gangopadhyay, D. Chakraborty, S. Dewanjee, S. Bhattacharya   +3 more
doaj   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Efficient protocol for in vitro clonal propagation of Rosa damascena Mill. and its comparison with conventional propagation method

Растениевъдни науки, 2018
In the present study a comparison is made between the best variants of medium for multiplication and rooting selected in the previous experiments in culture of nodal segments at two main Bulgarian oil-bearing genotypes aiming to develop effective ...
Veselina Badzhelova, Violeta Bozhanova
doaj  

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Production and rooting of cordia - Cordia trichotoma (Vell.) Arrab. ex Steud. mini-cuttings collected from ministumps of asexual and seminal origin

Ciência Rural, 2015
This study aimed to evaluate the production of cordia (Cordia trichotoma) ministumps of seminal and asexual origin, as well as the effect of the naphthaleneacetic acid (NAA) on the rooting of mini-cutitings.
Paula Kielse, Dilson Antônio Bisognin, Kelen Lencina Haygert, Uilian Stefanello Mello, Nathalia Pimentel, Marcelo Artur Raube   +5 more
doaj   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source