ABSTRACT The exponential rise in antimicrobial resistance has highlighted the urgent need for the development of alternative antibacterial strategies, including phage‐derived and engineered protein agents such as endolysins and artilysins. In this study, we report the rational design, expression, and functional characterization of novel artilysins ...
Farhat Ansari, Tarushi, Vandan Nagar
wiley +1 more source
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
Maintaining genetic stability in sweet potato: epigenetic insights into propagation and drought tolerance. [PDF]
Dhungana A +6 more
europepmc +1 more source
Toward clone‐on‐a‐chip: Ethical and legal considerations for organ‐on‐a‐chip evolution
The term “clone‐on‐a‐chip (CoC)” is introduced as a conceptual warning for personalized organ‐on‐a‐chip platforms and not to suggest technological feasibility, where a CoC ethical discussion extends beyond issues arising from the requirements for informed consent, property rights, commercialization efforts, and cell sourcing to include potentially ...
Muhammed Erkan Karabekmez +6 more
wiley +1 more source
Genomic Signatures of Somatic Mutation and Selection Shape Distinct Clonal Lineages in <i>Bougainvillea × buttiana</i> 'Miss Manila' Bud Sport. [PDF]
Meng H +5 more
europepmc +1 more source
RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad +5 more
wiley +1 more source
Kin discrimination in plants: overview and implications for population and community ecology
ABSTRACT Following the discovery of identity discrimination, particularly self and kin discrimination amongst plant competitors, research on interplant interactions has advanced significantly within plant physiology and evolutionary ecology. This review synthesizes current knowledge on how both self and kin discrimination influence plant growth ...
Akira Yamawo
wiley +1 more source
Domestication and genome evolution in <i>Allium</i> crops: From hybrid origins to breeding perspectives. [PDF]
Harding EA +3 more
europepmc +1 more source
Abstract Maintaining consistent quality in the manufacturing of biotherapeutic proteins in mammalian cell culture is challenging, with unplanned deviations causing inconsistencies and potential batch failure. Current methods for monitoring and controlling critical process parameters (CPPs) rely on slow, labor‐intensive offline analyses.
Matthew Banner +12 more
wiley +1 more source
Micropropagação e conservação de Vriesea reitzii e Vriesea friburgensis var. paludosa [PDF]
Alves, Glaise Mara
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