Results 191 to 200 of about 21,253 (264)

Model‐Enabled Knowledge Transfer Across Cell Lines, Culture Scales and Conditions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Mechanistic models are central to quantitative understanding and optimization of Chinese hamster ovary (CHO) cell culture processes, but their utility is often restricted by parameter sets calibrated for specific cell lines, scales, or operating conditions.
Luxi Yu, Antonio del Rio Chanona, Cleo Kontoravdi   +2 more
wiley   +1 more source

Genome-wide SNP analysis reveals genetic diversity and structure of wild and cultivated olives (Olea europaea L.) in Oman. [PDF]

Sci Rep
Al-Yahyai RA, Halo BA, Al-Subhi AM, Yaish MW.   +3 more
europepmc   +1 more source

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco, Kevin J. Ruiz‐Márquez, Rachel Moen, Irina Trenary, Xiaolin Zhang, Xiaowen Wang, Malik Padellan, Henry Lin, Jamey D. Young   +8 more
wiley   +1 more source

Exploring Duckweed Diversity at the Dawn of Its Cultivation Era: The Invaluable Legacy of the Landolt Collection. [PDF]

Plants (Basel)
Morello L, Lee Y, Braglia L.
europepmc   +1 more source

Polycationic Peptide Engineering of Phage Endolysins Expands Host Range and Enhances Antibacterial and Antibiofilm Activities Against Bacillus Species

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The exponential rise in antimicrobial resistance has highlighted the urgent need for the development of alternative antibacterial strategies, including phage‐derived and engineered protein agents such as endolysins and artilysins. In this study, we report the rational design, expression, and functional characterization of novel artilysins ...
Farhat Ansari, Tarushi, Vandan Nagar
wiley   +1 more source

Optimization of somatic embryogenesis protocol for Hevea brasiliensis clones RRIM 600 and REYAN 88-13. [PDF]

J Genet Eng Biotechnol
Dessailly F, Zhe L, Martin F, Petit-Briand J, Montoro P, Leclercq J.   +5 more
europepmc   +1 more source

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

Ectomycorrhizal Symbiosis as a Bio-Enhancement Strategy for Transplantation of Somatic Embryo-Derived <i>Pinus elliottii</i>. [PDF]

Plants (Basel)
Tian ZX, Ke X, Ji XY, Chen XY, Zhu LH.
europepmc   +1 more source

Temperature-Dependent Clonal and Species-Level Growth Variation in <i>Spirodela</i>, <i>Landoltia</i>, <i>Lemna</i>, and Interspecific <i>Lemna</i> Hybrids. [PDF]

Plants (Basel)
Mascheretti I, Mallardi A, Liberatore C, Martinelli T, Lauria M.   +4 more
europepmc   +1 more source

Breaking self-incompatibility for diploid hybrid potato breeding: advances, mechanisms, and emerging technologies. [PDF]

Front Plant Sci
Wang Y, Lin T, Wang Z, Fan L, Wang Y, Jiao X, Wang W, Zong X, Chen J, Yin Y.   +9 more
europepmc   +1 more source