Results 71 to 80 of about 21,253 (264)

Dynamic Regulation of Endogenous Transcription Factor Hubs at Single‐Molecule Resolution

Advanced Science, EarlyView.
This study combines single‐molecule microscopy and genome editing to characterize the dynamic behaviors of endogenous oncofusion transcription factor EWS::FLI1 in Ewing sarcoma cells. EWS::FLI1 forms neomorphic hubs that dynamically assemble and dissolve. The hubs are regulated during mitosis, by RNA, and by specific chemicals.
Shawn Yoshida, Yanghao Zhong, Akiko Kumagai, William G. Dunphy, Shasha Chong   +4 more
wiley   +1 more source

Production and rooting of cordia - Cordia trichotoma (Vell.) Arrab. ex Steud. mini-cuttings collected from ministumps of asexual and seminal origin

Ciência Rural, 2015
This study aimed to evaluate the production of cordia (Cordia trichotoma) ministumps of seminal and asexual origin, as well as the effect of the naphthaleneacetic acid (NAA) on the rooting of mini-cutitings.
Paula Kielse, Dilson Antônio Bisognin, Kelen Lencina Haygert, Uilian Stefanello Mello, Nathalia Pimentel, Marcelo Artur Raube   +5 more
doaj   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Sexual reproduction vs. clonal propagation in the recovery of a seagrass meadow after an extreme weather event

Scientia Marina, 2019
Marine flowering plants can reproduce sexually and clonally, and the relative contribution of these two modes can be dependent on the environmental conditions.
Diogo Paulo, Onno Diekmann, Ana Alexandra Ramos, Filipe Alberto, Ester Alvares Serrão   +4 more
doaj   +1 more source

Exploring Genetic and Epigenetic Changes in Lingonberry Using Molecular Markers: Implications for Clonal Propagation. [PDF]

Curr Issues Mol Biol, 2023
Sharma U, Sikdar A, Igamberdiev AU, Debnath SC.   +3 more
europepmc   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Efeito dos reguladores de crescimento dicamba e picloram na embriogênese somática em Eucalyptus grandis Somatic embryogenesis in Eucalyptus grandis: effect of growth regulators dicamba and picloram

Revista Árvore, 2007
Este trabalho objetivou avaliar o efeito das auxinas dicamba e picloram na indução de embriogênese somática em embriões zigóticos maduros, cotilédones e hipocótilos de Eucalyptus grandis. Os calos foram induzidos em meio de cultura MS contendo dicamba (0,
Miranda Titon, Aloisio Xavier, Wagner Campos Otoni, Sérgio Yoshimitsu Motoike   +3 more
doaj   +1 more source

Clonal Propagation and Assessment of Biomass Production and Saponin Content of Elite Accessions of Wild Paris polyphylla var. yunnanensis. [PDF]

Plants (Basel), 2023
Wang M, Li W, Qiang Q, Ma J, Chen J, Zhang X, Jia Y, Zhang T, Lin L.   +8 more
europepmc   +1 more source