Results 121 to 130 of about 88,997 (296)

Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life

Nature Communications
Clonal hematopoiesis becomes increasingly common with age, but its cause is enigmatic because driver mutations are often absent. Serial observations infer weak selection indicating variants are acquired much earlier in life with unexplained initial ...
Jesse Kreger, Jazlyn A. Mooney, Darryl Shibata, Adam L. MacLean   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Genetic variation among clones and sports of 'Pinot noir' (Vitis vinifera L.)

European Journal of Horticultural Science, 2007
J. Konradi, R. Blaich, A. Forneck
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Heritable variation in growth and biomass productivity in the clonal freshwater macroalga Oedogonium

, 2015
In an analogous manner tow hich selective breeding and propagation of heritable traits have improved terrestrial crops, the directional selection of target strains of commercial algae produced through clonal propagation is essential to realising their ...
Lawton, Rebecca J., Paul, Nicholas A., de Nys, Rocky, Carl, Christina   +3 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Meningococcal genetic variation mechanisms viewed through comparative analysis of Serogroup C Strain FAM18

, 2007
Copyright @ 2007 Public Library of ScienceThe bacterium Neisseria meningitidis is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx.
Parkhill Julian, Snyder, L., Rabbinowitsch, Ester, Davis, P., Rabbinowitsch, E, Claire Arrowsmith, Saunders, Nigel, Saunders, Nigel J., Barrell, B, Chillingworth, Tracey, Moule, Sharon, Tracey Chillingworth, Unwin, L., Bentley Stephen D, Maddison Mark, Jagels Kay, Vernikos George S, Saunders Nigel J, Maddison, Mark, Quail Michael A, Jagels, K, Unwin, Louise, Davis Paul H, Nancy E Holroyd, Maddison, M, Jagels, K., Chillingworth Tracey, Moule, S., Achtman, M., Mark Achtman, Unwin Louise, Unwin, L, Chillingworth, T., Quail, Michael A., Sharp Sarah, Stephen D Bentley, Rabbinowitsch Ester, Vernikos, GS, Julian Parkhill, Snyder Lori A. S, Vernikos, G., Moule, S, Arrowsmith Claire, Holroyd, NE, Parkhill, Julian, Snyder, Lori A.S., Carol Churcher, Holroyd, N., Churcher, Carol, Quail, M., Davis, PH, Churcher Carol, Achtman, M, Barrell, Bart, Quail, MA, Bart Barrell, Mark Maddison, Chillingworth, T, Parkhill, J, Moule Sharon, Arrowsmith, C, Churcher, C, Whitehead, Sally, Bentley, Stephen D., Nigel J Saunders, Barrell Bart, Arrowsmith, Claire, Arrowsmith, C., Cronin, A, Whitehead, S., Achtman, Mark, Snyder, LAS, George S Vernikos, Ester Rabbinowitsch, Louise Unwin, Churcher, C., Barrell, B., Jagels, Kay, Cronin, Ann, Cronin, A., Whitehead Sally, Bentley, SD, Saunders, NJ, Kay Jagels, Holroyd Nancy E, Bentley, S., Sharp, Sarah, Sharp, S., Rabbinowitsch, E., Parkhill, J., Lori A S Snyder, Paul H Davis, Sharp, S, Sally Whitehead, Achtman Mark, Maddison, M., Holroyd, Nancy E., Vernikos, George S., Davis, Paul H., Michael A Quail, Saunders, N., Whitehead, S, Ann Cronin, Cronin Ann, Sharon Moule, Sarah Sharp   +105 more
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source