Results 71 to 80 of about 55,715 (309)

Demonstration of T-Cell Monotypia Using Anti-TCRbeta1/2 (TRBC1/2) Immunostaining as a Rapid and Cost-Effective Alternative to PCR-Based Clonality Studies for the Diagnosis of T-Cell Lymphoma

Diagnostics
Background/Objectives: T-cell lymphomas are often histologically indistinguishable from benign T-cell infiltrates, and diagnosis typically relies on slow, complex, and expensive multiplexed PCR reactions, requiring significant training and experience to ...
Elizabeth J. Soilleux, Daniel T. Rodgers, Jinlong J. Situ, Shelley C. Evans, Venkata N. Konda, Han-Chieh Yang, Jianxiong Pang, Isabella Gilbey Smith, Pete Rajesh, Maryam Salimi, Soo Weei Ng, Julia Jones, Jodi L. Miller, Rachel Etherington, Margaret Ashton-Key, Graham Ogg   +15 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Pitfalls in TCR gene clonality testing: teaching cases [PDF]

, 2008
Clonality testing in T-lymphoproliferations has technically become relatively easy to perform in routine laboratories using standardized multiplex polymerase chain reaction protocols for T-cell receptor (TCR) gene analysis as developed by the BIOMED-2 ...
Patricia J. T. A. Groenen, Anton W. Langerak, Jacques J. M. van Dongen, Johan H. J. M. van Krieken, JJM Dongen Van, JJM Dongen Van, S Tonegawa, MM Davis, MC Zelm Van, WA Dik, T Quertermous, MP Lefranc, MP Lefranc, M Bottaro, AW Langerak, M Kneba, M Kneba, JJM Dongen Van, JHJM Krieken Van, PAS Evans, M Bruggemann, AW Langerak, Y Sandberg, Y Sandberg, C Matthews, S Lassmann, RF McClure, AM Halldorsdottir, AW Langerak, Y Sandberg, AW Langerak, AW Langerak, UR Malik, K Katchar, EM Leeuwen Van, LE Gamadia, DN Posnett, T Iijima, A Brauninger, RL Vargas   +39 more
core   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Body size and clonality consequences for sexual reproduction in a perennial herb of Brazilian rupestrian grasslands

Brazilian Journal of Biology
Body size is one of the most important factors regarding herbaceous perennial plants life-histories, and several fitness components of these organisms are related to size.
GR Demetrio, FF Coelho, MEA Barbosa
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Recurring outbreaks by the same Escherichia coli ST10 clone in a broiler unit during 18 months

Veterinary Research, 2022
The current investigation aimed at characterizing the cause of multiple disease outbreaks in the same broiler production unit during a course of 18 months. The outbreaks had mortality rates of up to 22%.
Anders Miki Bojesen, Umran Ahmed, Hanne Skaarup, Carmen Espinosa-Gongora   +3 more
doaj   +1 more source

When good bugs go bad: Epidemiology and antimicrobial resistance profiles of Corynebacterium striatum, an emerging multidrug-resistant, opportunistic pathogen [PDF]

, 2017
Infections with Corynebacterium striatum have been described in the literature over the last 2 decades, with the majority being bacteremia, central line infections, and occasionally, endocarditis.
Anderson, Neil, Burnham, Carey-Ann D, McMullen, Allison R, Shupe, Angela, Wallace, Meghan A   +4 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Determination of B-cell clonality in Hodgkin’s lymphoma

Клиническая онкогематология, 2014
B-cell origin of Hodgkin’s lymphoma was demonstrated using microdissection and single cell PCR of Reed-Sternberg and Hodgkin cells (R. Kuppers et al., 1994).
Yu. V. Sidorova, N. V. Ryzhikova, S. Yu. Smirnova, E. E. Nikulina, B. V. Biderman, A. M. Kovrigina, T. N. Moiseeva, N. N. Sharkunov, A. B. Sudarikov   +8 more
doaj   +1 more source