Results 71 to 80 of about 39,199 (304)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

T-cell clonality in immune responses.

, 1999
Recent methodological advances allow the analysis of clonal composition within T-cell subsets. Here, Mala Maini and colleagues review the available data on clonality in acute immune responses and steady-state situations.
Dellabona, P, Wack, A, Maini, MK, Beverley, PC, Beverley, Peter, Casorati, G   +5 more
core   +1 more source

HTLV-1 clonality during chronic infection and BLV clonality during primary infection [PDF]

, 2011
peer reviewedHTLV-1 clonality during chronic infection and BLV clonality during primary infection Nicolas A Gillet1,2*, Carol Hlela1, Tine Verdonck3, Eduardo Gotuzzo3, Daniel Clark3, Sabrina Rodriguez2, Nirav Malani4, Anat Melamed1, Niall Gormley5 ...
Tine Verdonck, Gormley, N., Charles R M Bangham, Carol Hlela, Nirav Malani, Bushman Frederic D, Gotuzzo, E., David Bentley, Anat Melamed, Gotuzzo Eduardo, Carter, R., Melamed Anat, Clark Daniel, Bangham Charles R M, Gillet Nicolas A, Rodriguez, Sabrina, Frederic D Bushman, Berry Charles, Eduardo Gotuzzo, Verdonck, T., Richard Carter, Gormley Niall, Charles Berry, Willems, L., Rodriguez Sabrina, Graham P Taylor, Bentley, D., Gillet, N., Hlela Carol, Bangham, C.R.M., Malani, N., Clark, D., Melamed, A., Niall Gormley, Taylor Graham P, Berry, C., Carter Richard, Luc Willems, Bentley David, Taylor, G.P., Malani Nirav, Nicolas A Gillet, Willems Luc, Bushman, F.D., Verdonck Tine, Daniel Clark, Hlela, C., Sabrina Rodriguez   +47 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Clonality Assessment by TRBC1 Immunohistochemistry

, 2023
Clonality assessment by TRBC1 immunohistochemistry in skin biopsies of cutaneous T-cell lymphoma compared to inflammatory dermatoses, with molecular data for comparisonTHIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Pulitzer, M (via Mendeley Data)
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

High-Sensitive TRBC1-Based Flow Cytometric Assessment of T-Cell Clonality in Tαβ-Large Granular Lymphocytic Leukemia

, 2022
Flow cytometric (FCM) analysis of the constant region 1 of the T-cell receptor β chain (TRBC1) expression for assessing Tαβ-cell clonality has been recently validated.
Susana Barrena, Villamor, Neus, Lima, Margarida, Jacques van Dongen, Alberto Orfao, Caldas, Carolina, F. Morán-Plata, Sheila Mateos, Carolina Caldas, Julia Almeida, Morán-Plata, F. Javier, Noemí Muñoz-García, Orfao, Alberto, Muñoz-García, Noemí, Margarida Lima, Barrena, Susana, Almeida, Julia, Mateos, Sheila, Dongen, J. J. M. van, Neus Villamor   +19 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Recurring outbreaks by the same Escherichia coli ST10 clone in a broiler unit during 18 months

Veterinary Research, 2022
The current investigation aimed at characterizing the cause of multiple disease outbreaks in the same broiler production unit during a course of 18 months. The outbreaks had mortality rates of up to 22%.
Anders Miki Bojesen, Umran Ahmed, Hanne Skaarup, Carmen Espinosa-Gongora   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source