Results 191 to 200 of about 661,172 (265)

Molecular mechanism of augmentation of oncogenic activity of MYC by TAF2 in HCC. [PDF]

J Biol Chem
Raha S, Zhang Q, Farrar D, Tseng C, Mendoza RG, Younis RM, Rodriguez KA, Iyer S, Subler MA, Windle JJ, Lai Z, Dozmorov M, Peng JC, Sarkar D.   +13 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Evaluating novel antibodies for cytokine profiling in the guinea pig model. [PDF]

Immunohorizons
Maristela L, Longworth A, Ackart DF, Lanni F, Gibb J, Freedman A, Miller OR, Cai L, Qi H, Baldwin SL, Larsen SE, Mehaffy C, Henao-Tamayo M, Coler RN, Podell BK.   +14 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Tissue-specific recombination-activated clonal and inducible transcription (TRAC-IT) enables controlled gene activation in stably marked tissues. [PDF]

Plant J
Wijsman T, Wittmer J, Winter R, Bruins T, van Zeijl A, Nijveen H, Scheres B, Heidstra R.   +7 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Protocol for cyclic DNA-damaging treatments to generate high mutational burden in the human A549 cell line. [PDF]

STAR Protoc
Imre G, Juhász S.
europepmc   +1 more source