Results 91 to 100 of about 532,228 (303)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Similar Code Detection and Elimination for Erlang Programs [PDF]

, 2010
A well-known bad code smell in refactoring and software maintenance is duplicated code, that is the existence of code clones, which are code fragments that are identical or similar to one another.
Huiqing Li, Simon Thompson, Thompson, Simon, Li, Huiqing   +3 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Attack-like camera angle.

, 2023
One of the hallmarks of the collective movement of large schools of pelagic fish are waves of shimmering flashes that propagate across the school, usually following an attack by a predator.
Assaf Pertzelan (16632091), Gil Ariel (203708), Moshe Kiflawi (134237)   +2 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone [PDF]

, 2011
We report on the comparative genomics and characterization of the virulence phenotypes of four <i>S. pneumoniae</i> strains that belong to the multidrug resistant clone PMEN1 (Spain^23F ST81).
Longwell Mark J., Mitchell, T.J., Dawid, S., Sá-Leão, Raquel, Tomasz, Alexander, Dahlgren Margaret E., Earl Joshua P., N Luisa Hiller, Ehrlich Garth D., Hillman, Todd A, Powell, E., Martin, D.P., Hu, F.Z., Tettelin Herve, Hu Fen Z., Hiller N. Luisa, Ehrlich, G.D., Sá-Leão, R., Tettelin, H., Azad Ahmed, Buchinsky, Farrel J, Dahlgren, Margaret E, Ehrlich, Garth D, Daugherty, S.C., Mitchell Timothy J., Timothy J Mitchell, Farrel J Buchinsky, Tomasz Alexander, Margaret E Dahlgren, Ezzo, S., Hiller, N.L., Eutsey, R.A., Powell, Evan, Martin Darren P., Ezzo, Suzanne, Post, J.C., Hiller, N Luisa, Longwell, Mark J, Benjamin Janto, Buchinsky, F.J., Evan Powell, Herve Tettelin, Garth D Ehrlich, de Lencastre Herminia, Dahlgren, M.E., Dawid, Suzanne, Rory A Eutsey, Daugherty Sean C., Tettelin, Herve, Daugherty, Sean C, Eutsey, Rory A, Alexander Tomasz, Fen Z Hu, Sá-Leão Raquel, Herminia de Lencastre, J Christopher Post, Dawid Suzanne, Post, J Christopher, Suzanne Dawid, Mark J Longwell, Powell Evan, Mitchell, Timothy J, Ahmed, Azad, Post J. Christopher, Joshua P Earl, Hillman Todd A., de Lencastre, H., Janto, Benjamin, Todd A Hillman, Janto Benjamin, Ezzo Suzanne, Earl, Joshua P, Tse, H., Raquel Sá-Leão, Eutsey Rory A., Darren P Martin, Buchinsky Farrel J., de Lencastre, Herminia, Ahmed, A., Suzanne Ezzo, Earl, J.P., Hu, Fen Z, Janto, B., Ahmed Azad, Sean C Daugherty, Martin, Darren P, Hillman, T.A., Longwell, M.J., Tomasz, A.   +88 more
core   +2 more sources

Level of Pest Infestation on Cocoa (Theobroma cacao L.) Variety BL-50 in Tanah Datar Regency, West Sumatera Province, Indonesia

Andalasian International Journal of Entomology
West Sumatra Province is one of the cocoa production centers in Indonesia. Cocoa farmers in the Lima Puluh Kota District in West Sumatera Province had successfully developed a superior clone of cocoa plants resulting from participatory selection, which ...
Zahlul Ikhsan, Muhammad Al-Ikhlas, Yaherwandi, Hasmiandy Hamid, Aulia Oktavia, Dandy Ahamefula Osibe   +5 more
doaj   +1 more source

Fast, Furious and Insecure: Passive Keyless Entry and Start Systems in Modern Supercars

Transactions on Cryptographic Hardware and Embedded Systems, 2019
The security of immobiliser and Remote Keyless Entry systems has been extensively studied over many years. Passive Keyless Entry and Start systems, which are currently deployed in luxury vehicles, have not received much attention besides relay attacks ...
Lennert Wouters, Eduard Marin, Tomer Ashur, Benedikt Gierlichs, Bart Preneel   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source