Results 191 to 200 of about 3,181,244 (296)

Scalable generation of hematopoietic stem cell-engineered off-the-shelf mono-specific cytotoxic T cells targeting solid tumors. [PDF]

Cell Rep Med
Zhu Y, Yu J, Kim YJ, Tian Y, Li Z, Chen Y, Lyu Z, Zhu E, Zhao AS, Ma N, Zhang C, Kramer A, Wilson M, Hon R, Wang YC, Lin S, Shen X, Hahn Z, Zhang Y, Wang A, Li YR, Yang L.   +21 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Robust and generalizable CNV detection for single-cell sequencing assays. [PDF]

Nucleic Acids Res
Moore TW, Mohammed H, Adey AC, Yardımcı GG.   +3 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Dual detection and novel genotypes of <i>Giardia</i> and <i>Leishmania</i> in <i>Ochotona curzoniae</i> from Zoige County, Qinghai-Tibet Plateau. [PDF]

Front Vet Sci
Deng L, Yin NC, Yi Z, Jike RH, Chen HX, Tang TC, Hao LL.   +6 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Long-read target enrichment sequencing for rAAV integration site analysis in engineered clones with targeted viral insertion. [PDF]

Mol Ther Nucleic Acids
Coratella E, Lemmens M, Oertli M, Gilbart Y, Davidsen K, Bontadelli L, Bohnert R, Rigal J, Bian J, Alpert T, Beibel M, Ruda V, Onishi-Seebacher M, Naumann U, Elhajouji A, Odermatt A, Hudry E, Libertini S.   +17 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

T cell fate is dictated by different antigen-presenting cells in response to dietary versus gut epithelial self-antigen. [PDF]

Immunity
Zhou YD, Brown H, Schaffer E, Taylor GM, Fiske KL, Komnick MR, Lopez S, Dermody TS, Esterházy D.   +8 more
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source