Results 211 to 220 of about 7,941 (270)

Optogenetic‐Controlled iPSC‐Based Vaccines for Prophylactic and Therapeutic Tumor Suppression in Mice

Advanced Science, EarlyView.
This study develops an a red/far‐red light‐controlled iPSC‐based vaccines (RIVA) based on the chimeric photosensory protein FnBphP and its interaction partner LDB3 for cancer immunotherapy. The RIVA preserves the multiple intrinsic tumor antigens of iPSCs and enables optogenetic control of the expression of the immune adjuvant type I interferon β under
Longliang Qiao, Lingxue Niu, Zhihao Wang, Di Dai, Shasha Tang, Xiaoding Ma, Zhenqiang Deng, Guiling Yu, Yang Zhou, Tao Yan, Xingwan Liu, Deqiang Kong, Linfeng Hu, Xiang Li, Junwei Zhao, Fengfeng Cai, Meiyan Wang, Haifeng Ye   +17 more
wiley   +1 more source

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

Programming ADAR-recruiting hairpin RNA sensor to detect endogenous molecules. [PDF]

Nucleic Acids Res
Qin PP, Chen PR, Tan L, Chu X, Ye BC, Yin BC.   +5 more
europepmc   +1 more source

Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets

Advanced Science, EarlyView.
This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu, Peng Peng, Yi‐Ning Wang, Mao‐Yang He, Shuang He, Chen‐Tao Jin, Liu Yang, Xi Wang, Jia‐Xi Zheng, Jie Gao, Cheng‐Ran Xu   +10 more
wiley   +1 more source

TopoQual polishes circular consensus sequencing data and accurately predicts quality scores. [PDF]

BMC Bioinformatics
Weerakoon M, Lee S, Mitchell E, Heaton H.   +3 more
europepmc   +1 more source

Scaffolding Protein ENH Promotes Tumor Angiogenesis and Growth Through Macrophage Recruitment and Polarization

Advanced Science, EarlyView.
In tumor cells, ENH prompts the interaction between YAP and KPNA2. This interaction enables YAP to translocate into the nucleus, where it enhances the transcription of CCL5. Consequently, this up‐regulation of CCL5 drives the infiltration of tumor‐associated macrophages (TAMs) and their polarization toward the M2 phenotype, ultimately facilitating ...
Yueli Shi, Zhiyong Xu, Huan Wang, Bufu Tang, Nueraili Maihemuti, Xinyuan Jiang, Xiuying Chen, Mingshu Xiao, Sujing Jiang, Yun Xu, Peng Xiao, Jiangnan Zhao, Kaiyue Zhang, Mengshu Li, Kai Wang   +14 more
wiley   +1 more source

Visual codon: a user-friendly Python program for viewing and optimizing gene GC content. [PDF]

PeerJ
Lin S, Xu F, Huang B, Zhao LL, Pan D, Lin S.   +5 more
europepmc   +1 more source

Unleashing quantum algorithms with Qinterpreter: bridging the gap between theory and practice across leading quantum computing platforms. [PDF]

PeerJ Comput Sci
Contreras-Sepúlveda W, Villegas-Martínez BM, Gesing S, Sánchez-Mondragón JJ, Sánchez-Pérez JC, Vidales-Basurto CA, Escobedo-Alatorre JJ, Torres-Palencia AD, Palillero-Sandoval O, Licea-Rodriguez J, Lozano-Crisóstomo N, García-Melgarejo JC, Palacios-Perez EN.   +12 more
europepmc   +1 more source

Efficient, cell-type-specific production of flavonols by multiplexed CRISPR activation of a suite of metabolic enzymes. [PDF]

Nat Commun
Houbaert A, Denervaud Tendon V, Hoermayer L, Morffy N, Strader LC, Geldner N.   +5 more
europepmc   +1 more source

FB5P-seq-mAbs: monoclonal antibody production from FB5P-seq libraries for integrative single-cell analysis of B cells. [PDF]

Front Immunol
Ado S, Dong C, Attaf N, Moussa M, Carrier A, Milpied P, Navarro JM.   +6 more
europepmc   +1 more source