Results 151 to 160 of about 11,282,248 (285)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Couple-close: Unified approach to semisaturated cyclic scaffolds. [PDF]

Science
Xie J, Zhao WY, Wang JZ, Lyon WL, Takanashi N, Long A, Sodano TM, Kelly CB, Bryan MC, MacMillan DWC.   +9 more
europepmc   +1 more source

Closing Editorial

Polymers
It is a real honor for me to be the Guest Editor of this Special Issue and to continue the project with the second edition “Sustainable Biopolymer-Based Composites: Processing, Characterization and Application II” [...]
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Screening of close contacts of pulmonary tuberculosis in an urban area in Shanghai, China: a cross-sectional study. [PDF]

BMC Infect Dis
Zhang S, Li F, Chen J, Wu Z, Ning C, Shen X, Yuan Z.   +6 more
europepmc   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Close, Yet Limited: The Conditional Nature of Family Involvement in the ICU. [PDF]

Nurs Crit Care
Falk AC, Österberg SA, Frank C.
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Efficacy of an AI-Enabled Low Glucose Prediction: A Pooled Performance Analysis With Capillary Blood Glucose as Ground Truth. [PDF]

J Diabetes Sci Technol
Glatzer T, Peak A, Leppäaho E, Lustenberger P, Herrero P, Andorrà M, van Maren E.   +6 more
europepmc   +1 more source

CLOSED EXTREMALS

Proceedings of the National Academy of Sciences, 1929
openaire   +3 more sources