Results 61 to 70 of about 175,978,596 (203)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Coordinative operations of distributed decision-making closed-loop supply chain: A review

, 2011
The problems and the causes of distributed decision-making in closed-loop supply chain are analysed in this paper. The importance and the significant of the researches for coordinate operations policy design for distributed decision-making closed-loop ...
Zhang Y(张毅), Liu B(刘彬), Xu JW(徐家旺), Zhao LQ(赵礼强)   +3 more
core   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Modelling decision tables from data. [PDF]

On most datasets induction algorithms can generate very accurate classifiers. Sometimes, however, these classifiers are very hard to understand for humans. Therefore, in this paper it is investigated how we can present the extracted knowledge to the user
Vanthienen, Jan, Wets, G, Timmermans, H
core  

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Representing fuzzy decision tables in a fuzzy relational database environment. [PDF]

In this paper the representation of decision tables in a relational database environment is discussed. First, crisp decision tables are defined. Afterwards a technique to represent decision tables in a relational system is presented.
Vanthienen, Jan, Wets, G, Chen, G
core  

Decision tables

, 2007
This article discusses an alternative approach in analyzing and modelling consumer decision processes: decision tables. Decision tables represent means of formalizing choice rules or heuristics.
Borgers, A.W.J., Timmermans, H.J.P., Middelkoop, van, M., Arentze, T.A.   +3 more
core   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Atoms in lattice of radical classes of lattice-ordered groups [PDF]

, 1993
summary:There are several special kinds of radical classes. For example, a product radical class is closed under forming product, a closed-kernel radical class is closed under taking order closures, a $K$-radical class is closed under taking $K ...
Ton, Dao-Rong
core   +1 more source