Results 281 to 290 of about 2,061,867 (378)

The Evolutionarily Conserved TPM1 Super‐Enhancer Drives Skeletal Muscle Regeneration via Mechanotransduction Signaling

open access: yesAdvanced Science, EarlyView.
By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang   +27 more
wiley   +1 more source

An intelligent closed-loop CES for depression treatment using brain signals and machine learning

open access: gold
Fahimeh Mosayebinejad   +7 more
openalex   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

open access: yesAdvanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu   +9 more
wiley   +1 more source

Analysis between Open Method and Closed Method of Reduction in Intra-articular Joint Depression Type of Calcaneal Fractures

open access: diamond
Anandkumar Sureshbhai Tailor   +4 more
openalex   +1 more source

Determination of the Exchange Current Density at Lithium │ Polymer Electrolyte Interfaces

open access: yesAdvanced Science, EarlyView.
This work presents a comprehensively validated method to determine the exchange current density (j0) at the interface of lithium metal and polymer electrolytes by combining electrochemical impedance spectroscopy with Bayesian inference and distribution of relaxation times analyses to successfully deconvolute solid electrolyte interphase and charge ...
Katrin Geng   +4 more
wiley   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

open access: yesAdvanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra   +23 more
wiley   +1 more source

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