Results 31 to 40 of about 62,471 (312)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Clinical and radiographic evaluation of closed and open methods of fracture management in dogs

Journal of Veterinary and Animal Sciences
The study was aimed to compare open and closed methods of fracture management in dogs. Twelve adult dogs aged above 18 months, were selected and divided into two groups.
Lakshmi Padmanabhan, Syam K. Venugopal, K.D. John Martin, Laiju M. Philip, Soumya Ramankutty, S. Anoop. S, R. Radhika   +6 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐Modifying Antirheumatic Drug

Arthritis Care &Research, EarlyView.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie, Timothy Beukelman, Nicholas P. McCormick, Jeffrey R. Curtis   +3 more
wiley   +1 more source

Failure after operative repair is higher for ballistic femoral neck fractures than for closed, blunt-injury fractures: a multicenter retrospective cohort study

Trauma Surgery & Acute Care Open
Introduction The purpose of this study was to describe the outcomes after operative repair of ballistic femoral neck fractures. To better highlight the devastating nature of these injuries, we compared a cohort of ballistic femoral neck fractures to a ...
Ranjan Gupta, Henry Tout Shu, Diane Ghanem, Davis L. Rogers, Oscar Covarrubias, Paul Izard, Jacques Hacquebord, Philip Lim, Greg M. Osgood, Babar Shafiq   +9 more
doaj   +1 more source

Closed reduction and percutaneous pinning for treatment of unstable lateral condyle fractures of the humerus in children

Frontiers in Pediatrics, 2023
ObjectiveIn the past, obviously displaced lateral condyle fractures of the humerus in children were treated satisfactorily with open reduction and internal fixation (ORIF).
Fei Qiao, Xiaohong Guan, Fei Jiang, Ping Lv   +3 more
doaj   +1 more source

The treatment of closed finger and metacarpal fractures

Deutsches Ärzteblatt international, 2023
Fractures of the fingers and metacarpal bones are the most common fracture type in the upper limb, with an incidence of 114 to 1483 per 100 000 persons per year. The clinical importance of closed finger and metacarpal fractures is often underestimated; inadequate diagnostic and therapeutic measures may result in serious harm.
Adrian, Cavalcanti Kussmaul, Titus, Kuehlein, Martin F, Langer, Ali, Ayache, Frank, Unglaub   +4 more
openaire   +2 more sources

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Accuracy of Ultrasonography in Confirmation of Adequate Reduction of Distal Radius Fractures

Emergency, 2013
Introduction: Restoration of normal anatomic alignment is a key component of the treatment of distal radius fractures (DRF). This study aimed to evaluate the accuracy of ultrasonography (US) in determining the adequacy of closed reduction in these ...
Mehrdad Esmailian, Ehsan Haj Zargarbashi, Babak Masoumi, Mehdi Karami   +3 more
doaj  

K-wire Fixation of Closed Hand Fractures Outside the Main Operating Room Does Not Increase Infections

Plastic and Reconstructive Surgery, Global Open, 2022
Background:. Closed reduction and internal fixation (CRIF) of closed hand fractures in the main operating room (OR) is much more expensive than outside of the OR. However, there is a reluctance to fix fractures out of the OR due to the perceived increase
Joshua A. Gillis, MD, Jan Lalonde, BN, David Alagar, MD, Canadian K-wire Consortium, Alain Azzi, MD, Donald H. Lalonde, MD, Murray Allen, Aslan Baradaran, Michael Brennan, Jevon Brown, Earle Campbell, Geethan Chandran, Geoffrey Cook, Michel Daigle,, Genevieve Dostaler, Donald Fitzpatrick, Valerie Hurdle, Abeer Kalandar, Matthew Laschuk, Matthew McRae, Daniel McKee, Bertrand Perey, Christian Petropolis, Emmanuel Salib, Osama Samargandi, Christian Schrag, Shane Seal, Hanni Shash, Leif Sigurdson, David Slawaska, Anna Steve, David Tang, Christopher Thomson, Dominique Tremblay, Jason Williams, Alison Wong   +35 more
doaj   +1 more source