Results 131 to 140 of about 987,806 (296)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The closed-loop economy

International Journal of Design & Nature and Ecodynamics, 2016
The economy is modeled as an engineering pumping system. At the start, no control is used; thus, the open-loop system is established. Flow, or analogously GDP, is sent from a pump to a storage tank (analogously, inventories). Control is then applied where investment (flow out of the tank) is controlled via the interest rate. Thus, the open loop becomes
openaire   +1 more source

Closed-loop two-echelon repairable item systems [PDF]

, 2003
In this paper we consider closed loop two-echelon repairable item systems with repair facilities both at a number of local service centers (called bases) and at a central location (the depot).
J. C. W. Van Ommeren, J. C. W. Van Ommeren, L. Spanjers, L. Spanjers, W. H. M. Zijm, W. H. M. Zijm   +5 more
core   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Closed-loop versus open-loop “remind-to-move” treatment using wearables for hemiparetic upper extremity in patients after stroke: A proof-of-concept study

Wearable Technologies
This is a proof-of-concept study to compare the effects of a 2-week program of “Remind-to-move” (RTM) treatment using closed-loop and open-loop wearables for hemiparetic upper extremity in patients with chronic stroke in the community.
Kenneth N. K. Fong, Jasmine P. Y. Pak, Alissa H. L. Koo, Maggie M. K. Szeto, Natalie M. T. Wong, Keily K. Y. Yau, Sharon F. M. Toh, Vivian W. Lou, Hector W. H. Tsang, Gary K. K. Lau   +9 more
doaj   +1 more source

A compensatory algorithm for the slow-down effect on constant-time-separation approaches [PDF]

In seeking methods to improve airport capacity, the question arose as to whether an electronic display could provide information which would enable the pilot to be responsible for self-separation under instrument conditions to allow for the practical ...
Abbott, Terence S.
core   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Effect of Multiple Models of Closed-Loop Transfer Functions on Inter-Harmonic Oscillation Characteristics of Grid-Connected PMSG

CSEE Journal of Power and Energy Systems
Establishing a suitable closed-loop transfer function model for the grid-connected PMSG system is the key basis in performing inter-harmonic characteristics analysis. Multiple closed-loop transfer functions can be constructed when different components of
Jingyi Li, Jianjun Yang, Xiaorong Xie, Haozhi Li, Ke Wang, Zhaohui Shi   +5 more
doaj   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source