Results 71 to 80 of about 4,315,423 (298)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Proposing Model for Master Planning of Sustainable Supply Chain with Considering Integration of Physical and Financial Flow [PDF]

چشم‌انداز مدیریت صنعتی, 2018
Balance growth in economic, social and environmental dimensions, and integrity of financial and physical flow of supply chain can ensure long-term success of any supply chain.
Amir Salar Mohammadi, Akbar Alem Tabriz, Mir Saman Pishvaee   +2 more
doaj  

Towards reducing electronic waste in a sustainable closed-loop supply chain [PDF]

Journal of Applied Research on Industrial Engineering
The increasing use of electronic goods worldwide has led to a significant increase in the amount of waste generated from their consumption, resulting in a primary environmental concern.
Pooria Malekinejad, Seyed Mirfakhradini, Ali Morovati Sharifabadi, Seyed Zanjirchi   +3 more
doaj   +1 more source

A Closed-Loop Logistics Model for Green Supply Chain Management

, 2011
Recently, with the environmental crisis, Green supply chain management (or GSCM), and in particular closed loop supply chain model, has received considerable attention by researchers.
A. Shemshadi, A. H. Basiri, M. J. Tarokh
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Designing a Closed-Loop Supply Chain for Aluminum Engine Manufacturing

, 2007
The closed-loop supply chain of an aluminum enginemanufacturing operation is investigated. The push for therecycling of aluminum components in auto industry ismotivated by profit incentives (i.e., the recovery of avaluable resource) as well as by legal ...
Duan, Yi, Lashkari, R.S.
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

A Multi-Objective MILP Model for Sustainable Closed-Loop Supply Chain Network Design: Evidence from the Wood–Plastic Composite Industry

Mathematics
Environmental concerns and the increasing scarcity of resources force decision makers in the supply chain to consider reuse and re-production. Closed loop supply chain is a fundamental concept that has attracted the attention of many researchers due to ...
Sahel Jebreili, Reza Babazadeh, Saeed Fazayeli, Mehdi A. Kamran, Amir Reza Gharibi   +4 more
doaj   +1 more source