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Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source

Compromise kinetic-fluid model of electrons dynamics in electric propulsion devices with closed electrons drift as an alternative to the hybrid PIC-Fluid method

Авіаційно-космічна техніка та технологія
Electric propulsion devices with closed electron drift include Hall effect thrusters, plasma-ion thrusters with a radial magnetic field, and helicon thrusters, which are sources of plasma, ions, and electrons. Within the framework of the hybrid PIC-Fluid
Serhii Nesterenko, Huang Zhihao, Shahram Roshanpour +2 more
doaj +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source

Design of a Motor-Torsion Driven 3D-Printed Left Ventricular Mock Circulation System and Hemocompatibility Assessment

Applied Sciences
In vitro testing of ventricular assist devices, constructing a mock circulation system that reproduces physiological cardiac function, is critical. However, current ventricular simulators often lack biomimetic fidelity and may introduce hemolysis and ...
Qingyang Cheng +6 more
doaj +1 more source

Confinement Efficiency and Stability of a Toroidal Magnetized Plasma Device with Sheared Magnetic Field Lines using an Internal Ring Conductor

, 2012
In a new toroidal laboratory plasma device including a poloidal magnetic field created by an internal circular conductor, the confinement efficiency of the magnetized plasma and the turbulence level are studied in different situations. The plasma density
Pierre, Thiery
core +5 more sources

Composite Electrospun Fibers Containing Optimized B‐ and Cu‐Doped Bioactive Glass Sol‐Gel Particles for Potential Soft Tissue Engineering Applications

Advanced Engineering Materials, EarlyView.
This article describes the preparation and characterization of poly(ε‐caprolactone) electrospun composite fibers incorporating sol‐gel‐derived bioactive glass particles doped with B and Cu. Scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, Fourier‐transform infrared spectroscopy, contact angle, acellular bioactivity, mechanical and ...
Elisa Piatti +5 more
wiley +1 more source

Experimental demonstration of advanced ISO-FLUX equilibrium control during the first JT-60SA operational phase under DEMO-relevant conditions

Nuclear Fusion
In the control of large superconducting tokamaks, particularly for devices like DEMO reactors, where no stabilizing plates or in-vessel coils can be mounted due to the existence of tritium breeding blankets, position, shape, and current of plasmas must ...
S. Inoue +9 more
doaj +1 more source

Evaluation of systemic absorption and bronchodilator effect of glycopyrronium bromide delivered by nebulizer or a dry powder inhaler in subjects with chronic obstructive pulmonary disease

Respiratory Research, 2019
Background Effective bronchodilator therapy depends upon adequate drug deposition in the lung. COPD patients who are unable to administer medications efficiently with conventional inhalers may benefit from the use of a nebulizer device.
Brian R. Leaker +7 more
doaj +1 more source

Fabrication of Embedded Microvalve on PMMA Microfluidic Devices through Surface Functionalization [PDF]

, 2008
The integration of a PDMS membrane within orthogonally placed PMMA microfluidic channels enables the pneumatic actuation of valves within bonded PMMA-PDMS-PMMA multilayer devices.
Ng, S. H., Toh, A. G. G., Wang, Z. F.
core +1 more source

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