Results 111 to 120 of about 34,610 (287)

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

Metabolic Oscillation Phenomena in Clostridia Species—A Review

Clostridia are interesting candidates for biotechnological applications due to their diverse and unique metabolic abilities. Particularly in continuous fermentation processes, productivity-decreasing metabolic oscillations have been reported in many ...
Annika Tyszak, Lars Rehmann
core   +1 more source

Defect‐engineered tungsten oxide nanowires as redox‐metabolic nanozymes for gut inflammation‐infection syndromes

BMEMat, EarlyView.
Defect‐engineered WO3 nanowires serve as a multifunctional nanozyme platform to treat IBD complicated by Salmonella co‐infection. By integrating catalytic ROS/RNS scavenging and targeted metabolic interference of pathogens via molybdenum substitution, these nanowires effectively resolve intestinal oxidative stress, inhibit infection, and restore ...
Yifan Yuan, Shipeng Zhang, Mingxuan Liu, Xurui Hou, Yizhi Dai, Weiyu Zhang, Zhongwei Yang, Xiaoyu Zhang, Jiahui Mao, Mingge Wang, Xin Yang, Ping Zhang, Hui Wang, Jing Liu   +13 more
wiley   +1 more source

Microbiome and Tumor Microenvironment Interactions: Advances From Ecological Niches to Precision Oncology

Cancer Nexus, EarlyView.
Tumor‐associated microbiota occupies spatially organized ecological niches and influence cancer progression by reshaping tumor‐cell signaling, metabolism, immunity, stromal remodeling, and therapeutic response. Integrating microbiome‐derived biomarkers, targeted microbial interventions, spatial multi‐omics, longitudinal monitoring, and AI may enable ...
Yiwen Zhang, Ji'an Liu, Jing Li, Xue Liu, Yang Su, Peng Luo, Yuhan Zhang, Zhengrui Li   +7 more
wiley   +1 more source

OVOMUCINASE ACTIVITY IN CLOSTRIDIA [PDF]

Journal of Bacteriology, 1959
J P, LOWENTHAL, S, BERMAN
openaire   +2 more sources

Phase I Evaluation of Siltartoxatug, a First‐in‐Class Anti‐Tetanus Monoclonal Antibody: Safety, Pharmacokinetics and Pharmacodynamics in Healthy Australian and Chinese Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Siltartoxatug, a first‐in‐class monoclonal antibody targeting tetanus toxin for post‐exposure prophylaxis, was evaluated in two phase I trials in Australian and Chinese healthy adults. In these randomized, double‐blind, placebo‐controlled, dose‐escalation studies, participants received a single intramuscular injection of siltartoxatug (10–250 μg/kg) or
Xinyu Liu, Zhigang Liu, Xiaohu Kuang, Yueming Wang, Xiaoyi Liu, Jiyuan Ding, Xia Zhou, Xin Zhou, Qianyu Liang, Meizhuo Zhang, Hao Zhao, Qingqing Tan, Weihong Zheng, Huaxin Liao, Charlotte Lemech, Wanmei Wang   +15 more
wiley   +1 more source

Relative abundance of (A) Firmicutes/Clostridia/…/LachnoXIVa and (B) Firmicutes/Clostridia/…/LachnoIV in blood samples collected at baseline and 15 minutes after exercise challenge in ME/CFS patients and healthy controls.

, 2015
Relative abundance of (A) Firmicutes/Clostridia/…/LachnoXIVa and (B) Firmicutes/Clostridia/…/LachnoIV in blood samples collected at baseline and 15 minutes after exercise challenge in ME/CFS patients and healthy controls.
Sanjay K. Shukla (250572), Thao Le (711567), Dane Cook (838789), Steven J. Schrodi (94581), Jacob Meyer (838790), Derek Clevidence (838791), Suzanne D. Vernon (374886), Charles E. Robertson (138101), Daniel N. Frank (158306), Steven Yale (838792)   +9 more
core   +1 more source

Ketogenic diet fails to mitigate seizures and neuroinflammatory responses in a mouse model of virus‐induced epilepsy

Epilepsia, EarlyView.
Abstract Objective The ketogenic diet (KD) is a high‐fat, low‐carbohydrate intervention widely used to treat drug‐resistant epilepsy, thought to reduce seizures through a combination of metabolic, neuronal, and microbiota‐dependent mechanisms. Additionally, recent studies suggest that the anticonvulsant effects of KD require the gut microbiota, with ...
Casey H. Meili, Kaitlyn Allen, Daniel J. Doty, Sofia Del Fiol, Ana Beatriz DePaula‐Silva   +4 more
wiley   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Editorial: Development and Application of Clostridia as Microbial Cell-Factories for Biofuels and Biochemicals Production

Frontiers in Bioengineering and Biotechnology, 2022
Hongxin Fu, Shang-Tian Yang
doaj   +1 more source