Results 131 to 140 of about 277,449 (338)

Effects of Clostridium perfringens iota toxin in the small intestine of mice [PDF]

, 2017
Iota toxin is a binary toxin solely produced by Clostridium perfringens type E strains, and is structurally related to CDT from C. difficile and CST from C. spiroforme.
Bruzzone, Octavio Augusto, Cangelosi, Adriana, Dailoff, Gabriela Cecilia, Díaz Carrasco, Juan María, Fernandez Miyakawa, Mariano Enrique, Geoghegan, Patricia, Leiva, Carlos Leónidas, Redondo, Enzo Alejandro, Redondo, Leandro Martin   +8 more
core   +1 more source

Precision microbiome restoration of bile acid-mediated resistance to Clostridium difficile

Nature, 2014
The gastrointestinal tracts of mammals are colonized by hundreds of microbial species that contribute to health, including colonization resistance against intestinal pathogens.
C. Buffie, V. Bucci, R. Stein, Peter T. McKenney, Lilan Ling, Asia Gobourne, Daniel No, Hui Liu, M. Kinnebrew, A. Viale, E. Littmann, M. V. D. van den Brink, R. Jenq, Y. Taur, C. Sander, J. Cross, Nora C. Toussaint, J. Xavier, E. Pamer   +18 more
semanticscholar   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

EVALUATION AND COMPARISON OF DNA EXTRACTION KITS FOR THE DETECTION OF Clostridium difficile IN SPIKED AND FIELD FAECES FROM PIGLETS BY USING REAL-TIME PCR

Slovenian Veterinary Research, 2017
In complex samples (faeces, soil, food, etc.), Clostridium difficile is often present in the form of dormant spores that cause reduced effectiveness of DNA extraction.
Jana Avberšek, Urška Zajc, Igor Gruntar, Brane Krt, Matjaž Ocepek   +4 more
doaj   +1 more source

Restrictive antibiotic stewardship associated with reduced hospital mortality in gram-negative infection [PDF]

, 2017
Introduction: Antimicrobial stewardship has an important role in the control of Clostridium difficile infection (CDI) and antibiotic resistance. An important component of UK stewardship interventions is the restriction of broad-spectrum beta-lactam ...
Helps, Alieen, Irvine, Sharon C., Jones, Brian L., Ritchie, Neil D., Robb, Fiona, Seaton, R. Andrew   +5 more
core   +1 more source

Clostridium difficile Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms

BioMed Research International, 2018
Clostridium difficile (C. difficile) is the most prevalent causative pathogen of healthcare-associated diarrhea. Notably, over the past 10 years, the number of Clostridium difficile outbreaks has increased with the rate of morbidity and mortality.
Saeed S. Banawas
semanticscholar   +1 more source

Resveratrol attenuates areca nut extract‐induced chronic colitis by suppressing pyroptosis of intestinal epithelial cells via modulating cGAS/STING signaling

VIEW, EarlyView.
Areca nut extract (ANE), commonly consumed in some cultures, can damage gut cells by triggering inflammation and cell death through a pathway called cGAS‐STING. This leads to the release of harmful inflammatory substances and weakens the gut barrier. Our study shows that resveratrol, a natural compound found in foods like grapes, can block this harmful
Jing Zhang, Muhammad Tufail, Yu‐Qi Huang, Can‐Hua Jiang, Ning Li   +4 more
wiley   +1 more source

Prevalencia y factores relacionados con la infección por Clostridium difficile en un centro hospitalario de alta complejidad en Cali (Colombia)

Infectio
Resumen Objetivos: Estimar la prevalencia y los factores relacionados con la infección por Clostridium difficile en un hospital de alta complejidad en Cali (Colombia). Métodos: Se realizó un estudio de casos y controles en pacientes que consultaron por
José Millán Oñate-Gutiérrez, María Virginia Villegas, Adriana Correa   +2 more
doaj   +1 more source

The Issue of Early Diagnosis of Intestinal Complications at Antibiotic Therapy in Children

Zdorovʹe Rebenka, 2015
The objective of the research was to improve the timely diagnosis of intestinal complications of antibiotic therapy, caused by Clostridium difficile infection in children.
O.A. Radutna, O.H. Ivanko, N.V. Kyzyma, O.S. Krut   +3 more
doaj   +1 more source

Perceptions of fecal microbiota transplantation for Clostridium difficile infection: factors that predict acceptance. [PDF]

, 2016
BackgroundDespite the effectiveness of fecal microbiota transplantation (FMT) for treating recurrent Clostridium difficile (C. difficile) infection, some patients are reluctant to accept this therapy.
Chen, Lea Ann, Hirsh, Jacqueline, Malter, Lisa, Mone, Anjali, Park, Leslie, Poles, Michael A, Price, Jennifer C, Tzimas, Demetrios   +7 more
core   +1 more source