Results 51 to 60 of about 462,658 (268)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Turbulence Closure With Small, Local Neural Networks: Forced Two‐Dimensional and β‐Plane Flows

Journal of Advances in Modeling Earth Systems
We parameterize sub‐grid scale (SGS) fluxes in sinusoidally forced two‐dimensional turbulence on the β‐plane at high Reynolds numbers (Re ∼25,000) using simple 2‐layer convolutional neural networks (CNN) having only O(1000) parameters, two orders of ...
Kaushik Srinivasan, Mickaël D. Chekroun, James C. McWilliams   +2 more
doaj   +1 more source

PFO‐ACCESS: Augmenting Communications for Medical Care or Closure in the Evaluation of Patients With Stroke With Cardiac Shunts

Stroke: Vascular and Interventional Neurology
Background Patent foramen ovale (PFO) contributes to a quarter of embolic strokes of undetermined source. Although the benefit of PFO closure in selected patients has been demonstrated, our system workflow still resulted in a low rate of PFO evaluation ...
Yasaman Pirahanchi, Benjamin Shifflett, Ehtisham Mahmud, Stefanie Brennan, Dawn M. Meyer, Melissa Mortin, Lovella Hailey, Jeffrey Bowers, Vikas Ravi, Julián Carrión, Reza Bavarsad, Kunal Agrawal, Royya Modir, Thomas Hemmen, Brett C. Meyer   +14 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

CLOSURE OF WOUNDS. [PDF]

JAMA: The Journal of the American Medical Association, 1903
The methods of closing wounds now in vogue are not the best. This opinion is based on personal experience, observation of the work of others, inquiry and reading, and is the excuse I have for the presentation of this paper. I do not claim either priority or originality in the methods of wound closure advocated in this paper.
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

“You can(’t) let go now”: Mystery boxes, quantum readings and very bright lights in Lost

TV Series, 2016
This paper intends to question certain narrative particularities of TV series Lost, taking into account its polarizing, if not fractured, reception. Building on the production and reception of the series (most notably the conception of a long term plot ...
Florent Favard
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

“[C]losure is something I may never obtain”: (In)consolation in Yewande Omotoso’s An Unusual Grief (2022) and Onyi Nwabineli’s Someday, Maybe (2022)

E-REA
Both Yewande Omotoso’s An Unusual Grief (2022) and Onyi Nwabineli’s Someday, Maybe (2022) address the shattering effects of grief after the sudden and tragic loss of a loved one to suicide.
Cédric COURTOIS
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source