Results 41 to 50 of about 19,426 (215)

Unilateral chronic angle-closure glaucoma in a pediatric patient with neurofibromatosis: a case report

Journal of International Medical Research, 2023
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease that causes multi-system damage. It is rarely associated with angle-closure glaucoma, especially in pediatric patients.
Mingming Jiang, Jing Zhang, Xiaomei Wan, Yichao Ding, Feijia Xie   +4 more
doaj   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Hydrochlorothiazide Sensitised Acetazolamide induced Bilateral Angle Closure Glaucoma with Choroidal Detachment after Cataract Surgery [PDF]

Journal of Clinical and Diagnostic Research, 2018
Sulfonamide (Sulfa) derived medications causing bilateral secondary angle closure glaucoma with choroidal effusion is a known but rare clinical entity.
Chitaranjan Mishra, T Sundar, Srinivas Sanjeev, Naresh Babu, Ramasamy Kim   +4 more
doaj   +1 more source

Artificial Intelligence in Ophthalmology: From Methodological Advances to Clinical Translation and Future Directions

Eye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) is reshaping ophthalmology from task‐specific image analysis toward multimodal, longitudinal, and clinically integrated decision support. This narrative review summarizes the methodological evolution of ophthalmic AI, including traditional machine learning, task‐specific deep learning, self‐supervised learning ...
Yuxin Liu, Hanruo Liu
wiley   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Strategies for Identification and Mitigation of Sanguinarine in Mustard Oil Adulterated by Argemone—A Comprehensive Review

Food Chemistry International, EarlyView.
Sanguinarine, a toxic alkaloid present in argemone, can lead to epidemic dropsy or chronic diseases through DNA intercalation and immune system suppression. Regulatory efforts face challenges due to economic motivations for adulteration as well as technical, social, and infrastructure barriers.
Gururaj Pejavara Narayana, Subhangi Panigrahi, Suresh Kumar Kalakandan, Hema Vincent, Ashish Rawson   +4 more
wiley   +1 more source

Precision Mapping of Retinal Disease: Identification of Differential Progression Trajectories via Imaging Phenomics

iMetaMed, EarlyView.
Applying single‐cell RNA‐seq techniques to large‐scale clinical phenotypic data enables the discovery of differential disease progression trajectories and the construction of data‐driven progression scores. These can then be integrated into precision medicine studies to investigate the drivers of patient‐specific disease outcomes. ABSTRACT We propose a
Christian Anderson, Liam Scott, Irene Leung, Ferenc Sallo, Catherine Egan, Tunde Peto, The MacTel Consortium, Melanie Bahlo, Martin Friedlander, Simone Tzaridis, Lea Scheppke, Roberto Bonelli   +11 more
wiley   +1 more source

Optic Nerve Thickness Assessed by Ocular Ultrasonography in Obstructive Sleep Apnea

Journal of Ultrasound in Medicine, EarlyView.
Objectives Obstructive sleep apnea (OSA) has been associated with various ocular complications, yet ultrasonographic evaluation of optic nerve thickness and its relationship with nocturnal hypoxemia remains poorly understood. This study aimed to evaluate optic nerve thickness and globe dimensions using ocular ultrasonography in patients with different ...
Buğra Kerget, Eyüp Çetin, Alperen Aksakal, Sırma Merve Çetin, Mustafa Buğra Coşkuner   +4 more
wiley   +1 more source

Acute bilateral angle closure glaucoma induced by methazolamide

Clinical Ophthalmology, 2013
Ahmad A Aref,1,2 Fouad E Sayyad,2 Bernadete Ayres,2 Richard K Lee21Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, 2Illinois Eye and Ear Infirmary, University of Illinois at Chicago School of Medicine, Chicago, IL ...
Aref AA, Sayyad FE, Ayres B, Lee RK
doaj  

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Med Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen, Chunrun Qu, Zeyu Wang, Jinglin Zhou, Hongwei Liu, Yingjie Li, Bowei Liu, Hao Zhang, Nan Zhang, Jingwei Zhang, Quan Cheng   +10 more
wiley   +1 more source