Results 91 to 100 of about 16,906 (266)

H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety

Advanced Science, EarlyView.
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou, Renbin Dou, Rong Wu, Yunyu Xu, Ying Wang, Peng Wang, Jinfu Li, Pengcheng Lu, Yu Mao, Jieying Qian, Yunjiao Zhang, Jiqian Zhang, Shasha Zhu   +12 more
wiley   +1 more source

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

Advanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo, Fangzhi Lou, Peiran Yang, Yu Zhang, Li Yan, Yunmei Dong, Bing Yang, Haiyang Wang, Yiyun Liu, Juncai Pu, Richard D. Cannon, Peng Xie, Ping Ji, Xin Jin   +13 more
wiley   +1 more source

Impact of the COVID-19 pandemic on the preschoolers mental development and education: Foreign experience of research

Современная зарубежная психология
Context and relevance. The impact of the COVID-19 pandemic on preschool children poses risks for developmental disabilities and difficulties, necessitating careful and comprehensive study. Objective.
E.S. Belova, N.B. Shumakova
doaj   +1 more source

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

„Egyre jobban érdekel, hogy mi történik velem”: A hála pszichológiai jelentősége időskorban

Studia Universitatis Babeş-Bolyai. Theologia Reformata Transylvanica
“I Am Increasingly Interested in What Is Happening to Me”: The Psychological Significance of Gratitude in Old Age. THEORETICAL BACKGROUND – According to the Hungarian Central Statistical Office (2024), individuals aged 65 and over represent 20.7% of the
Andrea FERENCZI, Sándor RÓZSA
doaj   +1 more source

Wearable Cooling Textiles of Thermal Conduction and Sweat Transfer for Personal Thermal Management

Advanced Science, EarlyView.
This study constructs a three‐dimensional thermal‐conductive pathway using biomass‐based fibers. The thermally conductive composite fibers were designed into Janus‐structured fabrics. The wearable cooling textile exhibits unidirectional moisture‐wicking properties (476% index), a high water evaporation rate (5209.92 g/m2/day), and effective skin ...
Jiajing Zhang, Jiahao Xu, Chunhua Zhang, Liangjun Xia, Xin Liu, Weilin Xu   +5 more
wiley   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

The Psychological and Economic Impact of Residents on the Closure of Bong Suwung Localization in Yogyakarta City

International Journal of Law and Society
Economic development in Indonesia aims to improve people's living standards and welfare, but challenges such as high poverty rates are still a significant problem, especially in the Special Region of Yogyakarta (DIY). This study aims to analyze the economic impact of the closure of the localization of Bong Suwung, which is one of the centers of ...
null Mujiyanto Mujiyanto, null Sugiyanto Sugiyanto   +1 more
openaire   +1 more source

Synergies in Agricultural Biodiversity Conservation: Decomposing the Interaction Between Nature Parks and Agri‐Environment Schemes

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Understanding how policy instruments with overlapping goals interact is crucial for leveraging their synergies. This study explores the mechanisms for regional nature parks (a form of protected areas that impose no restrictions on agriculture) to enhance the adoption of biodiversity‐conserving agri‐environment schemes (AES) in Switzerland ...
Yanbing Wang, Christian Ritzel, Antonia Kaiser, Gabriele Mack   +3 more
wiley   +1 more source

Patent foramen ovale closure in post-CVA/TIA patients: psychological distress, quality of life and optimism.

International journal of clinical practice, 2011
Patent foramen ovale (PFO) is common in asymptomatic adults, but imposes higher risk for transient ischaemic attack (TIA) or cerebral vascular accident (CVA). Trans-catheter closure of the PFO is now a common procedure in patients after cryptogenic CVA or TIA. No studies to date have assessed the psychological aspects of PFO closure.To assess the level
M, Cohen, M, Daniela, A, Lorber
openaire   +1 more source