We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong +5 more
wiley +1 more source
How university teachers' digital literacy influences their innovative ability: a system dynamics theoretical modeling and simulation study. [PDF]
Mao Z, Tong S, Jiang C, Yan S, Bai Y.
europepmc +1 more source
A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis
A preclinical mouse model of ovarian cancer–related depression was developed by combining intraperitoneal tumor cell injection, ovariectomy, and chronic restraint stress. The model replicates key clinical features including estrogen deficiency, depressive‐like behaviors, and tumor progression, and provides a reliable tool for studying the endocrine ...
Jiamin Liu +6 more
wiley +1 more source
Commentary: The quantitative paradigm and the nature of the human mind. The replication crisis as an epistemological crisis of quantitative psychology in view of the ontic nature of the psyche. [PDF]
Staller MS, Koerner S.
europepmc +1 more source
Research progress on biomarkers of traumatic brain injury
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen +8 more
wiley +1 more source
Bilateral Cheilorhinoplasty Techniques May Be Applied to an Incomplete Rare Facial Cleft: Case Report and Literature Review. [PDF]
Clark A, Gaal A.
europepmc +1 more source
Using Real-time Reporting to Investigate Visual Experiences in Dreams. [PDF]
Konkoly KR +8 more
europepmc +1 more source
Borderline Traits and the Simplification-Multidimensionality Tradeoff in Personality Profiling of Older Suicide Attempters: A Response to Satapathy and Zhao. [PDF]
Szücs A +6 more
europepmc +1 more source
Brief psychodynamic-interpersonal therapy for adults with a history of self-harm: the SafePIT RCT.
Guthrie E +15 more
europepmc +1 more source

