Results 261 to 270 of about 3,793,287 (374)

Evolution of Multivalent Aptamer Corona for High‐Throughput Multiplexed Detection of Multiple Cancers

open access: yesAdvanced Science, EarlyView.
A multivalent aptamer corona is evolved via established ProteoFish‐SELEX (systematic evolution of ligands by exponential enrichment) for high‐throughput multiplexed detection of multiple cancers. Clinical validation using multivalent aptamer corona demonstrated high accuracy and specificity in multiplexed detection of ovarian, lung, and colorectal ...
Mengjie Wang   +10 more
wiley   +1 more source

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

open access: yesAdvanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang   +17 more
wiley   +1 more source

Deep gradient reinforcement learning for music improvisation in cloud computing framework. [PDF]

open access: yesPeerJ Comput Sci
Alrowais F   +5 more
europepmc   +1 more source

An Enhanced Model for Intrusion Detection in a Cloud Computing Environment

open access: diamond
Odikayor-Ogbomo. I.F.   +3 more
openalex   +1 more source

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

open access: yesAdvanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu   +10 more
wiley   +1 more source

Sabatier‐Adjusted d‐Band Centers of Scalable Asymmetric Iron Sites toward Dynamic Nonradical Network for Fast Mineralization with Low‐Amount Oxidant

open access: yesAdvanced Science, EarlyView.
Asymmetric iron single‐atom catalysts with Sabatier‐adjusted d‐band centers overcome the inherent limitations of peroxymonosulfate (PMS) activation by establishing a synergistic nonradical pathway network, achieving exceptional pollutant mineralization (≈85%) at only one‐tenth conventional PMS dosage.
Yue Chen   +10 more
wiley   +1 more source

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