Results 271 to 280 of about 3,769,308 (372)

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Design of learning python programming for informatics education student using cloud computing technology based on google colaboratory

Syukri Adisakti Dainamang, Henry Praherdhiono, Yerry Soepriyanto   +2 more
openalex   +2 more sources

Blockchain driven medical image encryption employing chaotic tent map in cloud computing. [PDF]

Sci Rep
Shahid U, Kanwal S, Bano M, Inam S, Abdalla MEM, Shaikh ZA.   +5 more
europepmc   +1 more source

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source

A fact based analysis of decision trees for improving reliability in cloud computing. [PDF]

PLoS One
Asim Shahid M, Alam MM, Mohd Su'ud M.
europepmc   +1 more source

Hyperelastic Starch Hydrogel Configures Edible and Biodegradable All‐Components for Soft Robots

Advanced Science, EarlyView.
Hyperelastic starch hydrogel is tailored via a phase separation strategy of solvent‐antisolvent co‐modulation. The mechanical performance of starch hydrogel is widely tuned with maximum strains: 194.4–361.4%; maximum tensile stresses: 34–192 kPa; and Young's moduli: 36.0–205.8 kPa. Notably, the hydrogel achieves complete soil degradation within 24 days
Siyu Yao, Haohao Hu, Mengfan Zhang, Qingqing Zhu, Donghong Liu, Shaoxing Qu, Guoyong Mao, Enbo Xu   +7 more
wiley   +1 more source

Secure cloud computing: leveraging GNN and leader K-means for intrusion detection optimization. [PDF]

Sci Rep
Dugyala R, Chithaluru P, Ramchander M, Kumar S, Yadav A, Yadav NS, Elminaam DSA, Alsekait DM.   +7 more
europepmc   +1 more source

A Unique Chimeric RNA: ERCC1‐iASPP Drives Benzo[a]pyrene‐Induced Lung Carcinogenesis via Dual Coding and Non‐Coding Mechanisms

Advanced Science, EarlyView.
The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan, Mingyang Xiao, Liang Zhang, Shen Wang, Jiahang Wu, Kang Cao, Yujin Li, Guopei Zhang, Junwei Xie, Xiaobo Lu   +9 more
wiley   +1 more source

Auto-Scaling Techniques in Cloud Computing: Issues and Research Directions. [PDF]

Sensors (Basel)
Alharthi S, Alshamsi A, Alseiari A, Alwarafy A.   +3 more
europepmc   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source