Results 111 to 120 of about 858,800 (318)

Surface temperature sensitivities from cloud cover variations in the Hummel-Kuhn radiative-convective model with three different cloud approximations [PDF]

Tellus A: Dynamic Meteorology and Oceanography, 1981
In modeling the thermal structure of the atmosphere, the role of clouds is critically important. Clouds modify the solar flux distribution throughout the atmosphere, radiate significantly in the infrared, and provide large thermal reservoirs because of the large latent heat of water.
openaire   +2 more sources

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Quantum Neural Networks for Cloud Cover Parameterizations in Climate Models

Long-term climate projections require running global Earth system models on timescales of hundreds of years and have relatively coarse resolution (from 40 to 160 km in the horizontal) due to their high computational costs. Unresolved subgrid-scale processes, such as clouds, are described in a semi-empirical manner by so called parameterizations, which ...
Pastori, Lorenzo, Grundner, Arthur, Eyring, Veronika, Schwabe, Mierk   +3 more
openaire   +2 more sources

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

Advanced Science, EarlyView.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi   +19 more
wiley   +1 more source

Global and regional modeling of clouds and aerosols in the marine boundary layer during VOCALS: the VOCA intercomparison

, 2014
A diverse collection of models are used to simu- late the marine boundary layer in the southeast Pacific region during the period of the October-November 2008 VOCALS REx (VAMOS Ocean Cloud Atmosphere Land Study Re- gional Experiment) field campaign ...
M. Wyant, C. Bretherton, R. Wood, G. Carmichael, A. Clarke, J. Fast, R. George, W. Gustafson, C. Hannay, A. Lauer, Yanluan Lin, J. Morcrette, J. Mulcahy, P. Saide, S. Spak, Qing Yang   +15 more
semanticscholar   +1 more source

Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor‐Associated Macrophage‐Mediated Prostate Cancer Metastasis

Advanced Science, EarlyView.
This study investigates the role of M2 macrophage‐derived extracellular vesicles (M2 EVs) in prostate cancer (PCa) metastasis. Mechanistically, M2 EVs horizontally transfer TXNDC5 mRNA to PCa cells, where the molecule induces the mesenchymal‐like state (MLS), enhancing PCa migration and invasion.
Cong Hu, Tianyang Wu, Jiayi Wang, Xinxing Du, Xinrui Wu, Yanhao Dong, Zehong Peng, Penghui Liao, Zirui Guo, Zheyu Liu, Kenneth J Pienta, Yinjie Zhu, Jiahua Pan, Liang Dong, Wei Xue   +14 more
wiley   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

Comparison of model predicted cloud cover profiles with observations from ground and satellite

Meteorologische Zeitschrift, 2000
Cloud cover profiles predicted by a large-scale atmospheric model are directly compared with observations for three meteorologically different situations, i. e. a frontal system, a case of deep convection, and a case with low-level stratus. Observed profiles of cloud cover are inferred from measurements with a ground-based network of infrared ...
Erik van Meijgaard, Joop A. Konings, Arnout J. Feijt, André C.A.P. van Lammeren   +3 more
openaire   +2 more sources

Fermented Lacticaseibacillus Paracasei Cultures Ameliorate Colitis by Modulating Microbiota‐Derived Tryptophan Metabolism and Macrophage Polarization

Advanced Science, EarlyView.
A solid‐state fermented probiotic (PYW) is developed using wheat bran as substrate, containing high viable Lacticaseibacillus paracasei and bioactive metabolites. PYW alleviates intestinal inflammation by gut microbiota composition, enriching indole derivatives, activating aryl hydrocarbon receptor signaling, and regulating macrophage polarization. PYW
Heng Zhang, Jingzhou Sun, Xin Zheng, Huiqing Yang, Aowen Xie, Yuxuan Ding, Yuxia Mei, Jinshan Li, Yuanliang Hu, Min Ren, Yangyang Liu, Yunxiang Liang   +11 more
wiley   +1 more source

Completeness Assessment and Autonomous Resampling of Building Point Clouds with Aerial Priors [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Based on methods such as airborne oblique photogrammetry and laser scanning, high-precision urban 3D point clouds can be obtained. However, existing airborne 3D data acquisition techniques are prone to interference from dense building occlusions or ...
Y. Chen, S. Tang, W. Wang, T. Yu, L. Xie, X. Li, Y. Zhang, R. Guo   +7 more
doaj   +1 more source