PPY‐Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer
Pancreatic ductal adenocarcinoma features abundant stromal components that hinder therapy efficacy. Single‐cell RNA sequencing analysis combined with experiments identified PPY, a gastrointestinal hormone, as a novel inducer of immunosuppressive iCAFs. Mechanistic studies revealed that PPY activates the non‐canonical NF‐κB pathway via EGFR.
Mengdie Cao+14 more
wiley +1 more source
2D and 3D Scans of Granular Rock Material Heaps and Calibration Models. [PDF]
Klanfar M+3 more
europepmc +1 more source
On the Implementation of a Cloud-Based Computing Test Bench Environment for Prolog Systems [PDF]
Ricardo Gonçalves+2 more
openalex +1 more source
Self‐Induced A‐B‐A Structure Enables Efficient Wide‐Bandgap Perovskite Solar Cells and Tandems
DMFP penetrates to the bottom of the perovskite, forming an A‐B‐A sandwich structure with BzMIM Br, leading to strong interactions with the perovskite. In the vertical direction, utilizing multisite coordination with Pb ions forms internal molecular bridges, which not only improves crystallographic orientation but also suppresses halide phase ...
Xixi Yu+10 more
wiley +1 more source
Cloud computing convergence: integrating computer applications and information management for enhanced efficiency. [PDF]
Zhang G.
europepmc +1 more source
Neural Patterns of Social Pain in the Brain‐Wide Representations Across Social Contexts
Empathy arises from both physiological and social pain, yet their shared and context‐specific neural mechanisms remain unclear. Combining fMRI and multivariate pattern analysis, this study decodes overlapping empathy networks and distinct representations for social exclusion versus separation.
Xiaodong Zhang+11 more
wiley +1 more source
EcoTaskSched: a hybrid machine learning approach for energy-efficient task scheduling in IoT-based fog-cloud environments. [PDF]
Khan A+5 more
europepmc +1 more source
Uncover Hidden Physical Information of Soft Matter by Observing Large Deformation
Detecting internal abnormalities in soft matter remains challenging due to its heterogeneous nature. This study introduces a method that infers hidden physical properties by matching observed deformation with simulation through parallel Bayesian optimization.
Huanyu Yang+9 more
wiley +1 more source
A New Chicane Experiment In PEP-II to Test Mitigations of the Electron Cloud Effect for Linear Colliders [PDF]
M. Pivi+19 more
openalex