Results 51 to 60 of about 11,213 (177)

Prediction of dose reductions and impact of reduced starting doses of CDK4/6i on effectiveness in HR‐positive/HER2‐negative metastatic breast cancer: Real‐world data from the OPAL registry

open access: yesInternational Journal of Cancer, Volume 159, Issue 1, Page 244-256, 1 July 2026.
What's New? Balancing efficacy and tolerability is challenging in oncology, as standard dosing often prioritizes maximum tolerated doses over other patient needs. Here, the authors developed a predictive index to identify patients with increased probability of dose reduction in metastatic breast cancer and compared the real‐world effectiveness of ...
Patrick Marschner   +19 more
wiley   +1 more source

Um réquiem para Clovis

open access: yesBoletim do Museu Paraense Emílio Goeldi. Ciências Humanas
Resumo No início do século XXI, o tema povoamento inicial da América ainda é sinônimo de controvérsia. Para além da diversidade de interpretações sobre os contextos arqueológicos com datações pleistocênicas, as divergências sobrea origem dos povos ...
Adriana Schmidt Dias
doaj   +1 more source

A Delphi consensus for implementing genomic testing in unresectable or metastatic urothelial cancer

open access: yesBJU International, Volume 138, Issue 1, Page 144-155, July 2026.
Objectives To establish a UK consensus vision of a standardised genomic testing pathway in unresectable/metastatic urothelial cancer (mUC) with clear roles and responsibilities for multidisciplinary team (MDT) members and molecular pathology laboratory teams, and to agree how the pathway must evolve to accommodate emerging innovations.
Syed A. Hussain   +7 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1535-1555, June 2026.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Is There a Definitive Therapeutic Role of Vitamin E in The Prevention and/or Treatment of Human Male Infertility? [PDF]

open access: yesJournal of Liaquat National Hospital
Male factors are involved in the majority of infertile human patients worldwide. Free radicals and Reactive oxygen species (ROS)-mediated oxidative damage have been linked to male infertility by causing increased membrane lipid peroxidation, excessive ...
Tanveer Jilani, Sudhakar Pemminati
doaj   +1 more source

Early diagnosis of Parkinson's disease pathogenesis using biofluidic biomarkers with a focus on α-synuclein

open access: yesBrain Disorders
Parkinson's disease (PD) is the second most frequent neurodegenerative disease of the nervous system. The pathogenesis of PD is not yet fully understood; however, some investigations suggest that neuroinflammation, genetic mutations, and mitochondrial ...
N. Aghakhani   +4 more
doaj   +1 more source

Variety within Bigotry: From Individual to Systemic Monsterism in Buffy the Vampire Slayer [PDF]

open access: yesSlayage, 2023
Scholars debate and categorize varieties of bigotry in terms of responsibility, whether individual, institutional, structural, systematic, or systemic. Using the distance of fantasy narrative and “monsterism” in specific cases in Buffy the Vampire Slayer,
Rocha, James, Rocha, Mona
doaj  

CLÓVIS BEVILÁQUA E A FACULDADE DE DIREITO DO RECIFE

open access: yesRevista da Faculdade de Direito da Universidade Federal de Minas Gerais, 2014
(Aula inaugural do curso Clóvis Beviláqua em 11 de agôsto de 1959 no Instituto Histórico e Geográfico Brasileiro).
José Augusto
doaj   +4 more sources

A Boy with an Itch: A Case Report of Genital Nodular Scabies

open access: yesGlobal Pediatric Health
Scabies is an enormous global public health problem and one of the World Health Organization’s 20 most neglected tropical diseases. Scabies affects all groups with children and elderly, particularly in resource scarce countries, among the most vulnerable
Tony F. Bruno MD, MSC, CCFP   +1 more
doaj   +1 more source

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