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Clozapine—A dangerous drug in a clozapine-naïve subject
Forensic Science International, 2012Clozapine is a uniquely effective antipsychotic, but is very toxic in clozapine-naïve subjects. A 34-year-old male patient in a mental health facility, who was not prescribed clozapine, took 350 mg clozapine obtained from another patient at night. He was found dead the next morning. The presence of cardiomegaly related to obesity may have increased the
Stanworth, D. +2 more
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Journal of Clinical Psychopharmacology, 1989
The discovery of clozapine represents such a combination of paradoxes, luck and unfortunate incidents that some people believe the history of clozapine should be entitled "The Clozapine Story" (Stille and Fischer-Cornelssen 1988). One paradox lies in the fact that clozapine is at the same time a very old drug and also one of the newest and most modern ...
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The discovery of clozapine represents such a combination of paradoxes, luck and unfortunate incidents that some people believe the history of clozapine should be entitled "The Clozapine Story" (Stille and Fischer-Cornelssen 1988). One paradox lies in the fact that clozapine is at the same time a very old drug and also one of the newest and most modern ...
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L'Encephale, 1993
Clozapine does not constitute a first-line treatment due to the occurrence of agranulocytosis. However, the benefit risk/ratio fully justifies its use in two situations: resistance to neuroleptics, intolerance to neuroleptics. There are no internationally recognized objective criteria to define resistance.
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Clozapine does not constitute a first-line treatment due to the occurrence of agranulocytosis. However, the benefit risk/ratio fully justifies its use in two situations: resistance to neuroleptics, intolerance to neuroleptics. There are no internationally recognized objective criteria to define resistance.
openaire +2 more sources