Results 211 to 220 of about 45,210 (266)
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Current Medical Research and Opinion, 2001
Clozapine is a dibenzodiazepine derivative and a truly atypical anti-psychotic. Its therapeutic effects are probably mediated by dopaminergic and serotonergic activity. Although it appears to be the most effective antipsychotic drug for treatment-resistant schizophrenia, its general use is limited because of the risk of agranulocytosis.
M, Naheed, B, Green
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Clozapine is a dibenzodiazepine derivative and a truly atypical anti-psychotic. Its therapeutic effects are probably mediated by dopaminergic and serotonergic activity. Although it appears to be the most effective antipsychotic drug for treatment-resistant schizophrenia, its general use is limited because of the risk of agranulocytosis.
M, Naheed, B, Green
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American Journal of Psychiatry, 1990
Clozapine is a newly released antipsychotic that is associated with a higher prevalence of seizures than traditional neuroleptics. The authors describe four patients who developed seizure activity during clozapine treatment and provide recommendations for clinical management of this problem.
E, Haller, R L, Binder
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Clozapine is a newly released antipsychotic that is associated with a higher prevalence of seizures than traditional neuroleptics. The authors describe four patients who developed seizure activity during clozapine treatment and provide recommendations for clinical management of this problem.
E, Haller, R L, Binder
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Journal of Clinical Psychopharmacology, 1997
Two hundred thirty-eight patients treated with either haloperidol or clozapine were investigated to shed more light on the incidence and severity of antipsychotic-induced liver enzyme increase. Serum glutamic-pyruvic transaminase (SGPT) increase was most frequently seen in both treatment groups.
M, Hummer +5 more
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Two hundred thirty-eight patients treated with either haloperidol or clozapine were investigated to shed more light on the incidence and severity of antipsychotic-induced liver enzyme increase. Serum glutamic-pyruvic transaminase (SGPT) increase was most frequently seen in both treatment groups.
M, Hummer +5 more
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Clinical Neuropharmacology, 2015
Clozapine is a major atypical antipsychotic drug used in treatment-resistant schizophrenia (Patel and Allin. Ther Adv Psychopharmacol 2011;1:25-29). It interferes with dopamine binding to D1, D2, D3, and D5 receptors but has high affinity to D4. It also has an anticholinergic effect and antagonizes α-adrenergic, histaminergic, and serotoninergic ...
Valentina, Bruno +2 more
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Clozapine is a major atypical antipsychotic drug used in treatment-resistant schizophrenia (Patel and Allin. Ther Adv Psychopharmacol 2011;1:25-29). It interferes with dopamine binding to D1, D2, D3, and D5 receptors but has high affinity to D4. It also has an anticholinergic effect and antagonizes α-adrenergic, histaminergic, and serotoninergic ...
Valentina, Bruno +2 more
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Journal of Clinical Psychopharmacology, 1989
The discovery of clozapine represents such a combination of paradoxes, luck and unfortunate incidents that some people believe the history of clozapine should be entitled "The Clozapine Story" (Stille and Fischer-Cornelssen 1988). One paradox lies in the fact that clozapine is at the same time a very old drug and also one of the newest and most modern ...
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The discovery of clozapine represents such a combination of paradoxes, luck and unfortunate incidents that some people believe the history of clozapine should be entitled "The Clozapine Story" (Stille and Fischer-Cornelssen 1988). One paradox lies in the fact that clozapine is at the same time a very old drug and also one of the newest and most modern ...
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L'Encephale, 1993
Clozapine does not constitute a first-line treatment due to the occurrence of agranulocytosis. However, the benefit risk/ratio fully justifies its use in two situations: resistance to neuroleptics, intolerance to neuroleptics. There are no internationally recognized objective criteria to define resistance.
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Clozapine does not constitute a first-line treatment due to the occurrence of agranulocytosis. However, the benefit risk/ratio fully justifies its use in two situations: resistance to neuroleptics, intolerance to neuroleptics. There are no internationally recognized objective criteria to define resistance.
openaire +2 more sources