Results 301 to 310 of about 96,379 (348)
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Clozapine

Tijdschrift voor Geneeskunde, 2000
Schizofrene psychose treedt op in 0,3 tot 0,6% van de bevolking, ontstaat meestal op jongere leeftijd en kent ondanks de huidige therapeutische mogelijkheden een slechte prognose. Clozapine, een atypisch neurolepticum, kwam sinds de studie van Kane et al. in 1988 opnieuw in de belangstelling aangezien werd aangetoond dat met clozapine een therapeutisch
Vanderbruggen, Nathalie, Peuskens, Jozef
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Focus on Clozapine

Current Medical Research and Opinion, 2001
Clozapine is a dibenzodiazepine derivative and a truly atypical anti-psychotic. Its therapeutic effects are probably mediated by dopaminergic and serotonergic activity. Although it appears to be the most effective antipsychotic drug for treatment-resistant schizophrenia, its general use is limited because of the risk of agranulocytosis.
Ben Green, Miriam Naheed
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Systematic review and meta-analysis of rates of clozapine-associated myocarditis and cardiomyopathy

Australian and New Zealand journal of psychiatry (Print), 2020
Background: Clozapine is the most effective medication for treatment refractory schizophrenia, but is associated with cardiac adverse drug reactions. Myocarditis and cardiomyopathy are the most serious cardiac adverse drug reactions although reported ...
D. Siskind   +6 more
semanticscholar   +1 more source

Clozapine in the Elderly

Journal of Geriatric Psychiatry and Neurology, 1994
The authors reviewed the use of clozapine in eight patients over age 65 years with treatment-resistant psychoses. Six patients improved. Two patients became more confused. The authors suggest that clozapine be considered in treating elderly psychotic patients, and that its use need not be restricted to schizophrenic patients.
Douglas Kalunian, Frances R. Frankenburg
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Clozapine

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1991
Clozapine is a neuroleptic agent whose structure consists of a dibenzodiazepine derivative with a piperazinyl side chain. It has been classified as an atypical neuroleptic drug due to its unique neuropharmacologic profile. Clozapine has a weak binding affinity for dopamine D‐1 and D‐2 receptors by its slightly greater preference for D‐1 receptors, as ...
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Hepatotoxicity of Clozapine

Journal of Clinical Psychopharmacology, 1997
Two hundred thirty-eight patients treated with either haloperidol or clozapine were investigated to shed more light on the incidence and severity of antipsychotic-induced liver enzyme increase. Serum glutamic-pyruvic transaminase (SGPT) increase was most frequently seen in both treatment groups.
Martin Kurz   +5 more
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Pharmacological investigations of clozapine and clozapine analogues

2021
The author retains copyright of this thesis. It must only be used for personal non-commercial research, education and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission. For further terms on this licence: https://rightsstatements.org/page/InC-EDU/1.0/?language=en Contact ...
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Clozapine and seizures

Biological Psychiatry, 1995
Epileptiform EEG changes, myoclonus, and seizures are reported in some patients treated with clozapine. Although these are undesirable side effects, the excitation of specific neuronal networks by clozapine and other neuroleptics may be important for the therapeutic effect of this class of agents. In these experiments, intraperitoneal clozapine 2-16 mg/
Duane Denney, Janice R. Stevens
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Clozapine in China

Pharmacopsychiatry, 2008
Clozapine remains one of the most commonly used antipsychotic medications in China. As China has the largest population internationally on clozapine treatment, its experience and research findings are of keen interest to Western psychiatrists. However, most of the related papers have hitherto been published only in Chinese language journals.
Mao Px   +6 more
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The history of clozapine

Journal of Clinical Psychopharmacology, 1989
The discovery of clozapine represents such a combination of paradoxes, luck and unfortunate incidents that some people believe the history of clozapine should be entitled "The Clozapine Story" (Stille and Fischer-Cornelssen 1988). One paradox lies in the fact that clozapine is at the same time a very old drug and also one of the newest and most modern ...
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