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Psychotherapy and Psychosomatics, 2020
tial for high lethality due to its associated increases in clozapine levels. Moreover, clozapine and pneumonia have strong bidirectional associations, since clozapine may increase the risk of pneumonia [9].
Can-Jun Ruan +4 more
semanticscholar +1 more source
tial for high lethality due to its associated increases in clozapine levels. Moreover, clozapine and pneumonia have strong bidirectional associations, since clozapine may increase the risk of pneumonia [9].
Can-Jun Ruan +4 more
semanticscholar +1 more source
American Journal of Psychiatry, 1990
Clozapine is a newly released antipsychotic that is associated with a higher prevalence of seizures than traditional neuroleptics. The authors describe four patients who developed seizure activity during clozapine treatment and provide recommendations for clinical management of this problem.
Renée L. Binder, Ellen Haller
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Clozapine is a newly released antipsychotic that is associated with a higher prevalence of seizures than traditional neuroleptics. The authors describe four patients who developed seizure activity during clozapine treatment and provide recommendations for clinical management of this problem.
Renée L. Binder, Ellen Haller
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Optimizing clozapine treatment
Acta Psychiatrica Scandinavica, 2011Clozapine treatment remains the gold standard for treatment-resistant schizophrenia, but treatment with clozapine is associated with several side-effects that complicate the use of the drug. This clinical overview aims to provide psychiatrists with knowledge about how to optimize clozapine treatment.
Jimmi Nielsen +4 more
openaire +6 more sources
Psychological Medicine, 2019
Background Clozapine treatment increases the risk of agranulocytosis, but findings on the epidemiology of agranulocytosis have been inconsistent. This meta-analysis examined the prevalence of agranulocytosis and related death in clozapine-treated ...
Xiaohong Li +10 more
semanticscholar +1 more source
Background Clozapine treatment increases the risk of agranulocytosis, but findings on the epidemiology of agranulocytosis have been inconsistent. This meta-analysis examined the prevalence of agranulocytosis and related death in clozapine-treated ...
Xiaohong Li +10 more
semanticscholar +1 more source
Clinical Neuropharmacology, 2015
Clozapine is a major atypical antipsychotic drug used in treatment-resistant schizophrenia (Patel and Allin. Ther Adv Psychopharmacol 2011;1:25-29). It interferes with dopamine binding to D1, D2, D3, and D5 receptors but has high affinity to D4. It also has an anticholinergic effect and antagonizes α-adrenergic, histaminergic, and serotoninergic ...
Alicia Valiente-Gómez +2 more
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Clozapine is a major atypical antipsychotic drug used in treatment-resistant schizophrenia (Patel and Allin. Ther Adv Psychopharmacol 2011;1:25-29). It interferes with dopamine binding to D1, D2, D3, and D5 receptors but has high affinity to D4. It also has an anticholinergic effect and antagonizes α-adrenergic, histaminergic, and serotoninergic ...
Alicia Valiente-Gómez +2 more
openaire +2 more sources
Clozapine—A dangerous drug in a clozapine-naïve subject
Forensic Science International, 2012Clozapine is a uniquely effective antipsychotic, but is very toxic in clozapine-naïve subjects. A 34-year-old male patient in a mental health facility, who was not prescribed clozapine, took 350 mg clozapine obtained from another patient at night. He was found dead the next morning. The presence of cardiomegaly related to obesity may have increased the
Stanworth, D. +2 more
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Expert Review of Neurotherapeutics, 2004
Suicide accounts for approximately 10% of patient deaths in schizophrenia. The atypical antipsychotic clozapine (Clozaril), successful in treatment-resistant patients with schizophrenia, may have an additional antisuicidal effect. Numerous published reports, including the collaborative International Suicide Prevention Trial, have compared mortality ...
Robert Kerwin, A A Bolonna
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Suicide accounts for approximately 10% of patient deaths in schizophrenia. The atypical antipsychotic clozapine (Clozaril), successful in treatment-resistant patients with schizophrenia, may have an additional antisuicidal effect. Numerous published reports, including the collaborative International Suicide Prevention Trial, have compared mortality ...
Robert Kerwin, A A Bolonna
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Journal of Clinical Psychopharmacology, 2019
Purpose/Background In clozapine therapeutic drug monitoring (TDM) studies, Chinese reached the same concentrations using half the dosage Caucasians use.
Can-Jun Ruan +6 more
semanticscholar +1 more source
Purpose/Background In clozapine therapeutic drug monitoring (TDM) studies, Chinese reached the same concentrations using half the dosage Caucasians use.
Can-Jun Ruan +6 more
semanticscholar +1 more source
Expert Opinion on Drug Safety, 2019
Introduction: Clozapine remains the most effective antipsychotic for treatment-refractory schizophrenia. However, ~40% of the patients respond insufficiently to clozapine.
Kenya A Costa-Dookhan +10 more
semanticscholar +1 more source
Introduction: Clozapine remains the most effective antipsychotic for treatment-refractory schizophrenia. However, ~40% of the patients respond insufficiently to clozapine.
Kenya A Costa-Dookhan +10 more
semanticscholar +1 more source
Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine.
Archives of General Psychiatry, 1988J. Kane +3 more
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