Results 121 to 130 of about 1,868,629 (331)

Desarrollo de las destrezas lectoras a través de un club de lectores

open access: yesEducare, 2015
Las investigaciones psicolingüísticas sobre la lectura han develado que la lectura no es un acto pasivo de la comunicación, es un proceso eminentemente activo por parte del sujeto; por tal motivo, el hábito regular de la lectura enriquece el lenguaje ...
Josefina Calles
doaj  

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Structural subnetwork evolution across the life-span: rich-club, feeder, seeder

open access: yes, 2018
The impact of developmental and aging processes on brain connectivity and the connectome has been widely studied. Network theoretical measures and certain topological principles are computed from the entire brain, however there is a need to separate and ...
A Zalesky   +31 more
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Detecting rich-club ordering in complex networks

open access: yes, 2006
Uncovering the hidden regularities and organizational principles of networks arising in physical systems ranging from the molecular level to the scale of large communication infrastructures is the key issue for the understanding of their fabric and ...
A Barrat   +31 more
core   +2 more sources

Landscape of BRAF transcript variants in human cancer

open access: yesMolecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda   +5 more
wiley   +1 more source

The challenge of supporting networked personal inquiry learning across contexts [PDF]

open access: yes, 2010
Supporting learning across different contexts can be challenging. Defining formal, informal and nonformal learning is the subject of continuing debate as each can be difficult to describe.
Blake, Canan   +8 more
core  

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