Results 291 to 300 of about 308,086 (367)

Epigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

Respirology, EarlyView.
This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.
Ayaka Shiota, Keiko Kan‐o, Yumiko Ishii, Tomoaki Koga, Takeshi Sawada, Kei‐ichiro Yasunaga, Shingo Usuki, Tatsuya Katsuno, Shigesato Inoue, Tomohiro Ogawa, Akihiro Jo, Satoru Fukuyama, Mitsuyoshi Nakao, Hiroaki Ogata, Mizuho A. Kido, Sachiko Tsukita, Koichiro Matsumoto, Isamu Okamoto   +17 more
wiley   +1 more source

Image: Clubbing and hypoxia

Journal of the American College of Emergency Physicians Open
Jerome B. Balbin, Jessica Carlo
doaj   +1 more source

Clubbing of Fingers and Nails in Primary Hypertrophic Osteoarthropathy Type 1. [PDF]

Dtsch Arztebl Int
Pauly M, Hüffmeier U, Schmitt-Haendle M.   +2 more
europepmc   +1 more source

Impacts of a Century‐Old Urban Dam on Water Quality and Habitat Composition, Flint River, Flint, MI

River Research and Applications, EarlyView.
ABSTRACT Dams significantly influence river ecosystems worldwide, fragmenting habitats, altering sediment transport, and reducing biodiversity. Urban rivers are especially vulnerable, where dams compound stressors such as channelization, pollution, and degraded riparian zones. In response, dam removals are a growing restoration tool globally.
Chloe J. Summers, Heather A. Dawson
wiley   +1 more source

Two journeys, one diagnosis: exploring the clinical outcomes of twins with congenital myopathy. [PDF]

BMC Neurol
Pera MC, Pisanò G, Gnazzo M, Moretti S, Gambini L, Percesepe A, Esposito S, Perrone S.   +7 more
europepmc   +1 more source

Examining the Affordances of Engineering and Curricular Supports for Learning Among Emerging Bilingual Elementary Afterschool Students

Science Education, EarlyView.
ABSTRACT Engineering design provides students with unique opportunities to engage with disciplinary knowledge and practices by engaging with technologies and each other through the design process. In this paper, we identify how the co‐construction of an engineering afterschool club culture supported students’ engagement in epistemic practices of ...
Kathryn M. Bateman, Gregory J. Kelly, Peter R. Licona, Christine M. Cunningham   +3 more
wiley   +1 more source

Queer in Science, Technology, Engineering, and Mathematics: Following the Intersections of Queerness, Transness and Science Identities

Science Education, EarlyView.
ABSTRACT This multiple case study explores the intersections of queerness/transness and science education through a combined framework of queer theory, intersectionality, the construct of figured worlds and science identity. The study uses a life‐history approach to characterize the trajectories of three purposefully selected queer individuals who are ...
Nelly K. M. Marosi, Lucy Avraamidou, Mónica López López, Allison Jardim Gonsalves   +3 more
wiley   +1 more source

Band Acro-Osteolysis as a Less Common Radiologic Pattern in Systemic Scleroderma: A Case Report. [PDF]

Clin Med Insights Case Rep
Khezri S, Sahebari M, Aboutalebi F, Samadi MH, Ghamari M.   +4 more
europepmc   +1 more source

Collective (Un)Learning: A Self‐Examination of Science Teacher Educators' Evolving Translanguaging Pedagogy for Eliciting and Elevating Student Ideas

Science Education, EarlyView.
ABSTRACT This study centers the idea that it is not just what science teacher educators (STEs) teach, but how they teach it, that matters. To prepare future teachers who can enact more equitable and transformative reform‐oriented science instruction with multilingual learners, research must explore what STEs are doing, and how, to develop preservice ...
María González‐Howard, Karina Méndez Pérez, Sage Andersen, Carla Robinson, Leticia Garza   +4 more
wiley   +1 more source