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Lethal clues to cancer-cell vulnerability
Nature, 2019Cancer cells often have mutations in anticancer genes that make their survival dependent on other genes. The gene-editing approach CRISPR–Cas9 offers a way to identify such vulnerabilities. Cancer cells with microsatellite instability require WRN protein to survive.
Felix Y. Feng, Luke A. Gilbert
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HYPERREACTIVE ARTERIAL ENDOTHELIAL CELLS: A CLUE FOR THE TREATMENT OF ATHEROSCLEROSIS
Annals of the New York Academy of Sciences, 1976Arterial endothelial cells, which are capable of phagocytizing carbon particles of the same size as beta- and pre-beta-lipoprotein, were found only in endothelial cells of arterial segments susceptible to atheromatous changes in susceptible animal species, and the distribution closely corresponded to the susceptibility.
T, Shimamoto +5 more
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Multinucleate giant cells in neurofibromas: a clue to the diagnosis of neurofibromatosis
Journal of Cutaneous Pathology, 2009Background: A 54‐year‐old African‐American male patient underwent removal of several cutaneous neurofibromas. Histopathologic examination revealed a nonencapsulated, haphazardly arranged proliferation of slender spindle cells in a myxoid stroma consistent with neurofibroma.
Wirach M, Taungjaruwinai +1 more
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Respiratory Tract Symptoms as a Clue to Giant Cell Arteritis
Annals of Internal Medicine, 1984Although many manifestations of giant cell arteries are increasingly recognized, little attention has been paid to respiratory symptoms associated with this disorder. We report the cases of 16 patients with giant cell arteritis who had prominent symptoms related to the respiratory tract including cough, sore throat, and hoarseness.
T S, Larson +3 more
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Radial asymmetry in the topography of retinoblastoma Clues to the cell of origin
Ophthalmic Genetics, 1994Retinoblastoma is a malignancy of the human developing retina. In situ as well as in vitro studies have attributed tumoral histogenesis either to a primitive retinoblast with neuronal and glial differentiation potentials, or to a photosensory progenitor cell.
F L, Munier +3 more
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Cell migration in invertebrates: clues from border and distal tip cells
Current Opinion in Genetics & Development, 2001Recent studies in two invertebrate systems, border cells in Drosophila melanogaster and distal tip cells in Caenorhabditis elegans, have provided important insight into the mechanisms of directed cell migration. These migrating cells are guided by extracellular signals, such as EGF, TGF-beta and netrin.
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The Visualization of 'Yeast Cells' in Stools: A Clue to the Presence of Cryptosporidium
Archives of Pediatrics & Adolescent Medicine, 1987Sir.—Cryptosporidiumspecies have recently been recognized as a cause of gastrointestinal disease in immunocompetent healthy young children in day-care centers,1,2in family outbreaks,3and in developing countries, where they account for 3.6% to 7.6% of cases of acute diarrhea in preschool children.4 Patient Reports.—Over the last six months, three of 36
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Indian Journal of Sexually Transmitted Diseases and AIDS, 2007
KaleemJ Khan +3 more
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KaleemJ Khan +3 more
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“Shadow” Cells as Clues to Follicular Differentiation
The American Journal of Dermatopathology, 1988P A, Fanti, C, Varotti, A, Tosti
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“Shadow” Cells as Clues to Follicular Differentiation
The American Journal of Dermatopathology, 1987M, Jacobson, A B, Ackerman
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