Results 301 to 310 of about 129,580 (346)

Clues to B–cell memory

Nature Medicine, 1996
Nerve growth factor is a survival factor for memory B cells and is a potential target in the treatment of autoimmune disease.
openaire   +2 more sources

Lethal clues to cancer-cell vulnerability

Nature, 2019
Cancer cells often have mutations in anticancer genes that make their survival dependent on other genes. The gene-editing approach CRISPR–Cas9 offers a way to identify such vulnerabilities. Cancer cells with microsatellite instability require WRN protein to survive.
Felix Y. Feng, Luke A. Gilbert
openaire   +1 more source

New clues about T-cell antigen receptor complex function

Immunology Today, 1988
The emerging picture of the T-cell antigen receptor complex is that of an extraordinarily elaborate structure. The best-understood subunit is the Ti heterodimer, con- sisting of integral membrane glycoproteins bearing substantial structural and functional similarity to immunoglobulins 1. Somatic cell fusion and gene transfer experiments have shown that,
M A, Goldsmith, A, Weiss
openaire   +2 more sources

B-cell antigen receptor-induced apoptosis: looking for clues

Immunology Letters, 2005
Triggering of the B cell antigen receptor (BCR) can initiate divergent responses ranging from activation and cell division to apoptosis, depending on the differentiation stage and additional signals the cell receives. Despite considerable progress in unraveling general apoptosis pathways, the route from the BCR to apoptosis execution is still quite ...
Eric, Eldering, René A W, VanLier
openaire   +2 more sources

Discrete epithelioid cells: Useful clue to Hodgkin's disease cytodiagnosis

Diagnostic Cytopathology, 2002
AbstractDiagnosis of Hodgkin's disease is made with more confidence than diagnosis of non‐Hodgkin's lymphoma on cytology. This study was undertaken to describe the presence of granulomas and a new cytologic feature, discrete epithelioid cells (DECs), in smears from Hodgkin's disease.
Iyengar, Krishnan R., Mutha, Sucheeta
openaire   +3 more sources

Cell migration in invertebrates: clues from border and distal tip cells

Current Opinion in Genetics & Development, 2001
Recent studies in two invertebrate systems, border cells in Drosophila melanogaster and distal tip cells in Caenorhabditis elegans, have provided important insight into the mechanisms of directed cell migration. These migrating cells are guided by extracellular signals, such as EGF, TGF-beta and netrin.
openaire   +2 more sources

Heeding clues to giant cell arteritis

Postgraduate Medicine, 2004
To return to the case vignette, the new onset of headache in a 74-year-old woman with anemia and a markedly elevated ESR should alert the physician to the strong possibility of giant cell arteritis. Vision loss is the most significant potential early complication. Temporal artery biopsy is indicated, and treatment with corticosteroids should be started
Daniel M, Lichtstein, Luis R, Caceres
openaire   +2 more sources

Clue cells

Indian Journal of Sexually Transmitted Diseases and AIDS, 2007
KaleemJ Khan, Rajul Shah, Manjyot Gautam, Sharmila Patil   +3 more
openaire   +1 more source

Clues into Wnt cell surface signalosomes and its biogenesis

Trends in Biochemical Sciences
Wnt morphogens induce signaling via binding their extracellular receptors. Here, we discuss several recent structural studies showing how Wnts engage their receptors frizzled (FZD) and low-density lipoprotein receptor-related protein 5/6 (LRP5/6), how Cachd1 has been shown as an alternative initiator of Wnt signaling, and how lipidated Wnt may be ...
Philip Schmiege, Xiaochun Li
openaire   +2 more sources

Clues from cell metabolism

Nature, 2010
William G. Kaelin, Craig B. Thompson
openaire   +1 more source