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Exploration of Targeted Anti-tumor Therapy, 2021 Aim: Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer with high heterogeneity, rapid progression, and paucity of treatment options. The most effective chemotherapeutic drug used to treat TNBC is doxorubicin (Doxo) which
Garhima Arora +2 more
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Scientific Reports, 2021 Research on new cancer drugs is performed either through gene knockout studies or phenotypic screening of drugs in cancer cell-lines. Both of these approaches are costly and time-consuming.
Abhijit Paul +5 more
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Survival cluster analysis [PDF]
Proceedings of the ACM Conference on Health, Inference, and Learning, 2020 Conventional survival analysis approaches estimate risk scores or individualized time-to-event distributions conditioned on covariates. In practice, there is often great population-level phenotypic heterogeneity, resulting from (unknown) subpopulations with diverse risk profiles or survival distributions. As a result, there is an unmet need in survival
Chapfuwa, Paidamoyo +4 more
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Coral endosymbiont growth is enhanced by metabolic interactions with bacteria
Nature Communications, 2023 Bacteria are key contributors to microalgae resource acquisition, competitive performance, and functional diversity, but their potential metabolic interactions with coral microalgal endosymbionts (Symbiodiniaceae) have been largely overlooked.
Jennifer L. Matthews +10 more
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Population density and energy consumption: A study in Indonesian provinces
Heliyon, 2022 As the world’s fourth most populous country, the population growth rate in Indonesia is expected to stay high. Owing to a combination of high-speed urbanization and increasing population density, economic growth is predicted to increase the demand for ...
Irfani Fithria Ummul Muzayanah +4 more
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Coming home to die? The association between migration and mortality in rural Tanzania before and after ART scale-up [PDF]
Global Health Action, 2014 Background: Prior to the scale-up of antiretroviral therapy (ART), demographic surveillance cohort studies showed higher mortality among migrants than residents in many rural areas.
Francis Levira +2 more
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Frontiers in Cell and Developmental Biology, 2022 “Trim-Away” technology enables rapid degradation of endogenous proteins without prior modification of protein-coding genes or mRNAs through delivery of antibodies that target proteins of interest.
Rina Kunishige +6 more
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Cluster Correspondence Analysis [PDF]
Psychometrika, 2017 A method is proposed that combines dimension reduction and cluster analysis for categorical data by simultaneously assigning individuals to clusters and optimal scaling values to categories in such a way that a single between variance maximization objective is achieved.
van de Velden, M. +2 more
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Discriminative cluster analysis [PDF]
Proceedings of the 23rd international conference on Machine learning - ICML '06, 2006 Clustering is one of the most widely used statistical tools for data analysis. Among all existing clustering techniques, k-means is a very popular method because of its ease of programming and because it accomplishes a good trade-off between achieved performance and computational complexity.
Torre, Fernando De la, Kanade, Takeo
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Heliyon, 2020 Increasing electricity capacity to support economic growth has become a national development priority in Indonesia. The construction of a power plant needs to consider not only economic but also social and environmental impacts because the government can
Djoni Hartono +5 more
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